Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01514
Abstract: Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an increased reliance on NAD+ production pathways. This dependence may be exploited therapeutically through pharmacological targeting of NAMPT, the rate-limiting enzyme in the NAD+… read more here.
Keywords: cancer; nampt inhibitors; energy metabolism; beyond energy ... See more keywords
Review of various NAMPT inhibitors for the treatment of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.970553
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the NAD salvage pathway of mammalian cells and is overexpressed in numerous types of cancers. These include breast cancer, ovarian cancer, prostate cancer, gastric cancer, colorectal cancer,… read more here.
Keywords: cancer; inhibitors treatment; various nampt; review various ... See more keywords
Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies
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DOI: 10.3390/molecules28041897
Abstract: Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production. Despite the high efficacy of several… read more here.
Keywords: anticancer activities; nicotinamide phosphoribosyltransferase; hematological malignancies; nampt inhibitors ... See more keywords