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   Articles with "nanobody" as a keyword



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Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis and vascularization of spontaneous mouse mammary tumors.

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recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.13123

Abstract: Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis. In addition, MUC1 overexpression is closely interrelated… read more here.

Keywords: muc1; nanobody; muc1 tandem; tandem repeats ... See more keywords
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A Light‐Activatable Photocaged Variant of the Ultra‐High Affinity ALFA‐Tag Nanobody

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200079

Abstract: Nanobodies against short linear peptide‐epitopes are widely used to detect and bind proteins of interest (POI) in fusion constructs. Engineered nanobodies that can be controlled by light have found very recent attention for various extra‐… read more here.

Keywords: photocaged variant; affinity; photobody; alfa tag ... See more keywords
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Development of a mono-specific anti-VEGF bivalent nanobody with extended plasma half-life for treatment of pathologic neovascularization.

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recommendations! Published in 2019 at "Drug testing and analysis"

DOI: 10.1002/dta.2693

Abstract: Vascular Endothelial Growth Factor (VEGF) plays a crucial role in angiogenesis within solid cancers. Thus, targeting VEGF might be part of a feasible therapy for treating pathological neovascularization, and nanobodies - derived from Heavy chain-only… read more here.

Keywords: bivalent nanobody; nanobody; half life; vegf ... See more keywords
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Transient expression of anti-VEFGR2 nanobody in Nicotiana tabacum and N. benthamiana

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recommendations! Published in 2018 at "3 Biotech"

DOI: 10.1007/s13205-018-1500-z

Abstract: In human, the interaction between vascular endothelial growth factor (VEGF) and its receptor (VEGFR2) is critical for tumor angiogenesis. This is a vital process for cancer tumor growth and metastasis. Blocking VEGF/VEGFR2 conjugation by antibodies… read more here.

Keywords: transient expression; anti vefgr2; tobacco plants; nanobody ... See more keywords
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Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

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recommendations! Published in 2019 at "Cell"

DOI: 10.1016/j.cell.2018.12.006

Abstract: The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a… read more here.

Keywords: distinctive activation; activation mechanism; nanobody; angiotensin ... See more keywords
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Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109923

Abstract: The dense variant surface glycoprotein (VSG) coat of African trypanosomes represents the primary host-pathogen interface. Antigenic variation prevents clearing of the pathogen by employing a large repertoire of antigenically distinct VSG genes, thus neutralizing the… read more here.

Keywords: nanobody mediated; mediated macromolecular; vsg; nanobody ... See more keywords
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An ultrasensitive photoelectrochemical immunosensor by integration of nanobody, TiO2 nanorod arrays and ZnS nanoparticles for the detection of tumor necrosis factor-α

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recommendations! Published in 2017 at "Journal of Electroanalytical Chemistry"

DOI: 10.1016/j.jelechem.2017.09.008

Abstract: Abstract Dysregulation of human tumor necrosis factor α (TNF-α) production has been implicated in a variety of human diseases. Serum level of TNF-α is frequently detected in clinical diagnosis of cancer patients. Herein, we present… read more here.

Keywords: detection; nanobody; ultrasensitive photoelectrochemical; immunosensor ... See more keywords
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A novel immuno-gold labeling protocol for nanobody-based detection of HER2 in breast cancer cells using immuno-electron microscopy.

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recommendations! Published in 2017 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2017.05.008

Abstract: Immuno-electron microscopy is commonly performed with the use of antibodies. In the last decade the antibody fragment indicated as nanobody (VHH or single domain antibody) has found its way to different applications previously done with… read more here.

Keywords: nanobody; electron microscopy; immuno electron; microscopy ... See more keywords
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Tumor-specific near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer.

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recommendations! Published in 2020 at "Surgery"

DOI: 10.1016/j.surg.2020.02.020

Abstract: BACKGROUND Nanobodies, derived from camelid antibodies made of only heavy chains, are the smallest, biologic, antigen-binding fragments (~15kDa) with faster pharmacokinetics and better tumor penetration efficiency than standard antibodies. The present study evaluates the efficacy… read more here.

Keywords: nanobody; anti cea; pancreatic cancer; tumor ... See more keywords
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Shaping Nanobodies and Intrabodies against Proteoforms.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.3c00958

Abstract: Proteoforms expand genomic diversity and direct developmental processes. While high-resolution mass spectrometry has accelerated characterization of proteoforms, molecular techniques working to bind and disrupt the function of specific proteoforms have lagged behind. In this study,… read more here.

Keywords: rbd; chemistry; intrabodies proteoforms; shaping nanobodies ... See more keywords
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Fenobody: A Ferritin-Displayed Nanobody with High Apparent Affinity and Half-Life Extension.

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recommendations! Published in 2018 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.7b05217

Abstract: Nanobodies consist of a single domain variable fragment of a camelid heavy-chain antibody. Nanobodies have potential applications in biomedical fields because of their simple production procedures and low cost. Occasionally, nanobody clones of interest exhibit… read more here.

Keywords: nanobody; fenobody; life extension; apparent affinity ... See more keywords