Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.2c00220
Abstract: Recombinantly produced biotherapeutics hold promise for improving the current standard of care for snakebite envenoming over conventional serotherapy. Nanobodies have performed well in the clinic, and in the context of antivenom, they have shown the… read more here.
Keywords: generation multivalent; long neurotoxins; improved neutralization; nanobody based ... See more keywords
Detection of Acrylamide in Foodstuffs by Nanobody-Based Immunoassays.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01872
Abstract: Acrylamide is toxic aliphatic amide formed via the Maillard reaction between asparagine and reducing sugars during thermal processing of food. Herein, a specific nanobody termed Nb-7E against the acrylamide derivative xanthyl acrylamide (XAA) was isolated… read more here.
Keywords: acrylamide foodstuffs; based immunoassays; foodstuffs nanobody; detection ... See more keywords
Nanobody-Based Electrochemical Immunoassay for Sensitive Detection of Peanut Allergen Ara h 1.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00921
Abstract: Peanut is widely used for food supplementation with potential allergic reactions in infants and adults, which prompted the development of reliable and accurate detection of peanut allergens with emphasis on Ara h 1. In this… read more here.
Keywords: based electrochemical; immunoassay; nanobody based; detection peanut ... See more keywords
Nanobody-Based Apolipoprotein E Immunosensor for Point-of-Care Testing.
Sign Up to like & getrecommendations! Published in 2017 at "ACS sensors"
DOI: 10.1021/acssensors.7b00495
Abstract: Alzheimer's disease (AD) biomarkers can reflect the neurochemical indicators used to estimate the risk in clinical nephrology. Apolipoprotein E (ApoE) is an early biomarker for AD in clinical diagnosis. In this research, through bactrian camel… read more here.
Keywords: point care; nanobody based; immunosensor; care testing ... See more keywords
Nanobody-Based Lateral Flow Assay for Rapid Zika Virus Detection
Sign Up to like & getrecommendations! Published in 2025 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.4c00819
Abstract: Zika virus infections remain severely underdiagnosed due to their initial mild clinical symptoms. However, recent outbreaks have revealed neurological complications in adults and severe deformities in newborns, emphasizing the critical need for accurate diagnosis. Lateral… read more here.
Keywords: nanobody based; zika virus; nanobody; lateral flow ... See more keywords
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-09661-0
Abstract: Each year, snakebite envenoming claims thousands of lives and causes severe injury to victims across sub-Saharan Africa, many of whom depend on antivenoms derived from animal plasma as their sole treatment option1. Traditional antivenoms are… read more here.
Keywords: venom induced; nanobody based; based recombinant; antivenom ... See more keywords
Nanobody engineering for enhanced-sensitivity rapid COVID-19 tests.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d5nr02568k
Abstract: Nanobody-based diagnostics enable rapid and highly specific detection of infectious diseases, supporting early intervention and effective outbreak control. With their small size, high stability, and ease of production, nanobodies serve as promising alternatives to conventional… read more here.
Keywords: sars cov; covid; nanobody based; antibody based ... See more keywords
Abstract 1786: Mesothelin-targeting, nanobody-based CAR T cells effectively target solid tumors in fully immunocompetent hosts
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1786
Abstract: Nanobody-based chimeric antigen receptor (CAR) T cells are currently being tested in early phase clinical trials against blood and solid tumor antigens. Owing to the low molecular weight, increased stability, and low immunogenicity of nanobodies,… read more here.
Keywords: mesothelin; car; nanobody based; based car ... See more keywords
Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-023-02285-4
Abstract: The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic effects, have been developed. Adeno-associated virus (AAV)-mediated gene transfer represents an efficient approach to achieve… read more here.
Keywords: p2x7; based biologics; nanobody based; vector coding ... See more keywords
Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1005800
Abstract: Nanobodies are well suited for constructing biologics due to their high solubility. We generated nanobodies directed against CD38, a tumor marker that is overexpressed by multiple myeloma and other hematological malignancies. We then used these… read more here.
Keywords: chain antibodies; heavy chain; myeloma; nanobody based ... See more keywords
Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1012534
Abstract: Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor. ATP… read more here.
Keywords: based biologics; purinergic checkpoints; p2x7; nanobody based ... See more keywords