Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.2c00220
Abstract: Recombinantly produced biotherapeutics hold promise for improving the current standard of care for snakebite envenoming over conventional serotherapy. Nanobodies have performed well in the clinic, and in the context of antivenom, they have shown the… read more here.
Keywords: generation multivalent; long neurotoxins; improved neutralization; nanobody based ... See more keywords
Detection of Acrylamide in Foodstuffs by Nanobody-Based Immunoassays.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01872
Abstract: Acrylamide is toxic aliphatic amide formed via the Maillard reaction between asparagine and reducing sugars during thermal processing of food. Herein, a specific nanobody termed Nb-7E against the acrylamide derivative xanthyl acrylamide (XAA) was isolated… read more here.
Keywords: acrylamide foodstuffs; based immunoassays; foodstuffs nanobody; detection ... See more keywords
Nanobody-Based Electrochemical Immunoassay for Sensitive Detection of Peanut Allergen Ara h 1.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00921
Abstract: Peanut is widely used for food supplementation with potential allergic reactions in infants and adults, which prompted the development of reliable and accurate detection of peanut allergens with emphasis on Ara h 1. In this… read more here.
Keywords: based electrochemical; immunoassay; nanobody based; detection peanut ... See more keywords
Nanobody-Based Apolipoprotein E Immunosensor for Point-of-Care Testing.
Sign Up to like & getrecommendations! Published in 2017 at "ACS sensors"
DOI: 10.1021/acssensors.7b00495
Abstract: Alzheimer's disease (AD) biomarkers can reflect the neurochemical indicators used to estimate the risk in clinical nephrology. Apolipoprotein E (ApoE) is an early biomarker for AD in clinical diagnosis. In this research, through bactrian camel… read more here.
Keywords: point care; nanobody based; immunosensor; care testing ... See more keywords
Abstract 1786: Mesothelin-targeting, nanobody-based CAR T cells effectively target solid tumors in fully immunocompetent hosts
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1786
Abstract: Nanobody-based chimeric antigen receptor (CAR) T cells are currently being tested in early phase clinical trials against blood and solid tumor antigens. Owing to the low molecular weight, increased stability, and low immunogenicity of nanobodies,… read more here.
Keywords: mesothelin; car; nanobody based; based car ... See more keywords
Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1005800
Abstract: Nanobodies are well suited for constructing biologics due to their high solubility. We generated nanobodies directed against CD38, a tumor marker that is overexpressed by multiple myeloma and other hematological malignancies. We then used these… read more here.
Keywords: chain antibodies; heavy chain; myeloma; nanobody based ... See more keywords
Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1012534
Abstract: Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor. ATP… read more here.
Keywords: based biologics; purinergic checkpoints; p2x7; nanobody based ... See more keywords
Editorial: Nanobody-based cancer immunotherapy and immunoimaging
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1213386
Abstract: COPYRIGHT © 2023 Jafari, Maali, Shokrgozar and Sharifzadeh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,… read more here.
Keywords: editorial; editorial nanobody; based cancer; nanobody based ... See more keywords
The Development and Validation of a Novel Nanobody-Based Competitive ELISA for the Detection of Foot and Mouth Disease 3ABC Antibodies in Cattle
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2018.00250
Abstract: Effective management of foot and mouth disease (FMD) requires diagnostic tests to distinguish between infected and vaccinated animals (DIVA). To address this need, several enzyme-linked immunosorbent assay (ELISA) platforms have been developed, however, these tests… read more here.
Keywords: foot mouth; disease; nanobody based; competitive elisa ... See more keywords