Cascade-Responsive 2-DG Nanocapsules Encapsulate aV-siCPT1C Conjugates to Inhibit Glioblastoma through Multiple Inhibition of Energy Metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19285
Abstract: Aerobic glycolysis is the primary energy supply mode for glioblastoma (GBM) cells to maintain growth and proliferation. However, due to the metabolic reprogramming of tumor cells, GBM can still produce energy through fatty acid oxidation… read more here.
Keywords: energy metabolism; energy; nanocapsule; cascade responsive ... See more keywords
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Sign Up to like & getrecommendations! Published in 2019 at "Nature nanotechnology"
DOI: 10.1038/s41565-019-0539-2
Abstract: Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing system often require viral vectors, which pose safety concerns for therapeutic genome editing1. Alternatively, cationic liposomal components or polymers can be… read more here.
Keywords: gene editing; ribonucleoprotein complex; genome; nanocapsule ... See more keywords
Supramolecular nanocapsules as two-fold stabilizers of outer-cavity sub-nanometric Ru NPs and inner-cavity ultra-small Ru clusters.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale horizons"
DOI: 10.1039/d1nh00677k
Abstract: The synthesis of metallic nanoparticles (MNP) with high surface area and controlled shape is of paramount importance to increase their catalytic performance. The detailed growing process of NP is mostly unknown and understanding the specific… read more here.
Keywords: cavity; nanocapsule; sub nanometric; small clusters ... See more keywords
Optimal conditions for laser-induced heating of a double-shell spherical nanocapsule
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Physics"
DOI: 10.1063/1.4979095
Abstract: By virtue of the finite element method, the numerical simulations of the temperature field near a poly-layer spherical nanoparticle exposed to a pulsed optical radiation are carried out. Such particles model the double-shell nanocapsules with… read more here.
Keywords: conditions laser; shell; optimal conditions; nanocapsule ... See more keywords
Cationic nanocapsule suspension as an alternative to the sublingual delivery of nifedipine
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2023.2203201
Abstract: Abstract Nifedipine (NIFE) is a calcium channel blocker drug used to treat cardiovascular diseases, angina, and hypertension. However, NIFE is photolabile, has a short biological half-life, low aqueous solubility, and undergoes an intense first-pass effect,… read more here.
Keywords: nanocapsule suspension; nife; nanocapsule; cationic nanocapsule ... See more keywords
Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s221598
Abstract: Background Fabrication of a smart drug delivery system that could dramatically increase the efficiency of chemotherapeutic drugs and reduce the side effects is still a challenge for pharmaceutical researchers. By the emergence of nanotechnology, a… read more here.
Keywords: nanocapsule; drug; cancer; diagnosis therapy ... See more keywords
Natural Halloysite-Templated Synthesis of Highly Graphitic Boron-Doped Hollow Carbon Nanocapsule Webs
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12142352
Abstract: Hollow carbon nanocapsules have been attracting growing interest due to their fascinating characteristics and extensive potential applications. In this work, a novel natural halloysite-templated synthesis approach for highly graphitic boron-doped hollow carbon nanocapsule webs (B-HCNCWs)… read more here.
Keywords: hollow carbon; carbon; halloysite templated; nanocapsule ... See more keywords
Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.73104
Abstract: Rationale: Cancer immunotherapy has demonstrated significant antitumor activity in a variety of tumors; however, extensive infiltration of immunosuppressive tumor-associated macrophages (TAMs) in the glioblastoma (GBM) tumor microenvironment (TME) and the existence of the blood-brain barrier… read more here.
Keywords: trojan horse; immunotherapy; phagocytosis; nanocapsule ... See more keywords