Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201704490
Abstract: Chemotherapy suffers numbers of limitations including poor drug solubility, nonspecific biodistribution, and inevitable adverse effects on normal tissues. Tumor-targeted delivery and intratumoral stimuli-responsive release of drugs by nanomedicines are considered to be highly promising in… read more here.
Keywords: dual intratumoral; responsive releasing; redox enzyme; intratumoral redox ... See more keywords
Boosting Nanomedicine Efficacy with Hyperbaric Oxygen Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-58174-9_4
Abstract: Nanomedicine has been a hot topic in the field of tumor therapy in the past few decades. Because of the enhanced permeability and retention effect (EPR effect), nanomedicine can passively yet selectively accumulate at tumor… read more here.
Keywords: efficacy; nanomedicine; hbo therapy; therapy ... See more keywords
Harnessing nanomedicine for enhanced immunotherapy for breast cancer brain metastases
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-021-01039-9
Abstract: Graphical abstract Brain metastases (BMs) are the most common type of brain tumor, and the incidence among breast cancer (BC) patients has been steadily increasing over the past two decades. Indeed, ~ 30% of all patients with… read more here.
Keywords: brain metastases; breast cancer; nanomedicine; brain ... See more keywords
Perspectives on the past, present, and future of cancer nanomedicine.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2018.05.008
Abstract: The justification of cancer nanomedicine relies on enhanced permeation (EP) and retention (R) effect and the capability of intracellular targeting due primarily to size after internalization (endocytosis) into the individual target cells. The EPR effect… read more here.
Keywords: delivery; nanomedicine; cancer nanomedicine; perspectives past ... See more keywords
H2O2-responsive biodegradable nanomedicine for cancer-selective dual-modal imaging guided precise photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.03.042
Abstract: A tumor-related stimuli-activatable and biodegradable nanoplatform for tumor-selective imaging and effective photodynamic therapy (PDT) towards precision medicine is highly desirable but still greatly challenging. Here, we developed a novel H2O2-activatable and biodegradable nanomedicine (BSA-MBPB) by… read more here.
Keywords: photodynamic therapy; dual modal; imaging guided; modal imaging ... See more keywords
Time‐resolved fluorescence microscopy (FLIM) as an analytical tool in skin nanomedicine
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.01.005
Abstract: Graphical abstract Figure. No Caption available. Abstract The emerging field of nanomedicine provides new approaches for the diagnosis and treatment of diseases, for symptom relief, and for monitoring of disease progression. Topical application of drug‐loaded… read more here.
Keywords: microscopy flim; microscopy; fluorescence microscopy; skin ... See more keywords
Nanomaterials/microorganism-integrated microbiotic nanomedicine
Sign Up to like & getrecommendations! Published in 2020 at "Nano Today"
DOI: 10.1016/j.nantod.2020.100854
Abstract: Abstract Based on the great advances of the nanomaterials and nanotechnology in the last decade, nanomedicine combining the nanomaterials and nanobiotechnology has been attracting intensive attentions worldwide owing to its bright prospects in generating numerous… read more here.
Keywords: integrated microbiotic; nanomaterials microorganism; nanomedicine; microorganism integrated ... See more keywords
Nanomedicine promotes ferroptosis to inhibit tumour proliferation in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101908
Abstract: miR-101–3p may play a therapeutic role in various tumours. However, its anti-tumour mechanism remains unclear, and a definitive strategy to treat tumour cells in vivo is lacking. The objective of this study was to investigate… read more here.
Keywords: tumour proliferation; tumour cells; mir 101; proliferation ... See more keywords
Clot-Targeted Antithrombotic Liposomal Nanomedicine Containing High Content of H2O2-Activatable Hybrid Prodrugs.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20750
Abstract: Liposomes have been extensively explored as drug carriers, but their clinical translation has been hampered by their low drug-loading content and premature leakage of drug payloads. It was reasoned that vesicle-forming prodrugs could be incorporated… read more here.
Keywords: antithrombotic liposomal; clot targeted; targeted antithrombotic; liposomal nanomedicine ... See more keywords
In Situ Transformable Supramolecular Nanomedicine Targeted Activating Hippo Pathway for Triple-Negative Breast Cancer Growth and Metastasis Inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c05263
Abstract: As it is closely associated with tumor proliferation, metastasis, and the immunosuppressive microenvironment, the dysfunctional Hippo pathway has become an extremely attractive target for treating multiple cancers. However, to date, the corresponding chemotherapeutic nanomedicines have… read more here.
Keywords: metastasis; hippo pathway; situ; growth ... See more keywords
Sex as an important factor in nanomedicine
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23230-9
Abstract: Nanomedicine has demonstrated substantial potential to improve the quality and efficacy of healthcare systems. Although the promise of nanomedicine to transform conventional medicine is evident, significant numbers of therapeutic nanomedicine products have failed in clinical… read more here.
Keywords: medicine; sex important; nanomedicine; sex ... See more keywords