Indolactam Dipeptides as Nanomolar Gli Inhibitors.
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DOI: 10.1021/acsmedchemlett.1c00562
Abstract: The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including… read more here.
Keywords: dipeptides nanomolar; chemistry; indolactam dipeptides; gli inhibitors ... See more keywords