Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.
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DOI: 10.1016/j.ejmech.2016.11.004
Abstract: Current endocrine therapeutics for the estrogen-dependent disease endometriosis often lead to considerable side-effects as they act by reducing estrogen action systemically. A more recent approach takes advantage of the fact that the weak estrogen estrone… read more here.
Keywords: estrogen dependent; hsd1; estrogen; nanomolar ic50 ... See more keywords