The Efficacy of Nanoparticle Delivery to Hypoxic Solid Tumors by ciRGD Co-administration Depends on Neuropilin-1 and Neutrophil Levels.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300594
Abstract: The ability to improve nanoparticle delivery to solid tumors is an actively studied domain, where various mechanisms have been looked into. In previous work, w e have looked into nanoparticle size, tumor vessel normalization and… read more here.
Keywords: neutrophil levels; nanoparticle delivery; cirgd administration; solid tumors ... See more keywords
Nanoparticle delivery through single walled carbon nanotube subjected to various boundary conditions
Sign Up to like & getrecommendations! Published in 2018 at "Microsystem Technologies"
DOI: 10.1007/s00542-018-4191-9
Abstract: Dynamic behavior of single walled carbon nanotubes (CNTs) delivering a nanoparticle with constant velocity is investigated subject to various boundary conditions. The governing equation is derived based on nonlocal Euler–Bernoulli beam theory. The Vander Waals… read more here.
Keywords: boundary conditions; walled carbon; nanoparticle delivery; various boundary ... See more keywords
Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110196
Abstract: SUMMARY Vascular endothelium plays a crucial role in vascular homeostasis and tissue fluid balance. To target endothelium for robust genome editing, we developed poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG-b-PLGA) copolymer-based nanoparticle formulated with polyethyleneimine. A single… read more here.
Keywords: endothelium; plasmid dna; nanoparticle delivery; genome editing ... See more keywords
Nanoparticle delivery in vivo: A fresh look from intravital imaging
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102958
Abstract: Nanomedicine has proven promising in preclinical studies. However, only few formulations have been successfully translated to clinical use. A thorough understanding of how nanoparticles interact with cells in vivo is essential to accelerate the clinical… read more here.
Keywords: intravital imaging; vivo; nanoparticle delivery; delivery vivo ... See more keywords
Impact of Tumor Barriers on Nanoparticle Delivery to Macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00905
Abstract: The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the… read more here.
Keywords: nanoparticle delivery; delivery macrophages; delivery; impact tumor ... See more keywords
Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b02578
Abstract: MicroRNA-based therapy that targets cardiac macrophages holds great potential for treatment of myocardial infarction (MI). Here, we explored whether boosting the miRNA-21 transcript level in macrophage-enriched areas of the infarcted heart could switch their phenotype… read more here.
Keywords: cardiac macrophages; mirna mimic; myocardial infarction; nanoparticle delivery ... See more keywords
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01501
Abstract: Mutated RAS proteins are potent oncogenic drivers and have long been considered "undruggable". While RAS-targeting therapies have recently shown promise, there remains a clinical need for RAS inhibitors with more diverse targets. Small proteins represent… read more here.
Keywords: nanoparticle delivery; small proteins; lipid nanoparticle; delivery small ... See more keywords
Nanoparticle delivery of curcumin induces cellular hypoxia and ROS-mediated apoptosis via modulation of Bcl-2/Bax in human neuroblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr02770b
Abstract: In this study, several formulations of nanoceria and dextran-nanoceria with curcumin, each demonstrated to have anti-cancer properties, were synthesized and applied as treatment for human childhood neuroblastoma. The anti-cancer activities of these formulations were explored… read more here.
Keywords: curcumin induces; apoptosis; nanoparticle delivery; delivery curcumin ... See more keywords
Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2019.00415
Abstract: The exploitation of nanosized materials for the delivery of therapeutic agents is already a clinical reality and still holds unrealized potential for the treatment of a variety of diseases. This review discusses physiological barriers a… read more here.
Keywords: overcoming physiological; barriers nanoparticle; delivery yet; delivery ... See more keywords
Nanoparticle Delivery of Immunostimulatory Agents for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.37216
Abstract: Immunostimulatory agents, including adjuvants, cytokines, and monoclonal antibodies, hold great potential for the treatment of cancer. However, their direct administration often results in suboptimal pharmacokinetics, vulnerability to biodegradation, and compromised targeting. More recently, encapsulation into… read more here.
Keywords: delivery; nanoparticle delivery; immunostimulatory agents; cancer immunotherapy ... See more keywords