Spray-Dried Nanoparticle-in-Microparticle Delivery Systems (NiMDS) for Gene Delivery, Comprising Polyethylenimine (PEI)-Based Nanoparticles in a Poly(Vinyl Alcohol) Matrix.
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DOI: 10.1002/smll.201701810
Abstract: Nucleic acid-based therapies rely on efficient formulations for nucleic acid protection and delivery. As nonviral strategies, polymeric and lipid-based nanoparticles have been introduced; however, biological efficacy and biocompatibility as well as poor storage properties due… read more here.
Keywords: polyethylenimine; based nanoparticles; delivery; nanoparticle microparticle ... See more keywords
Nanoparticle-in-microparticle oral drug delivery system of a clinically relevant darunavir/ritonavir antiretroviral combination.
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DOI: 10.1016/j.actbio.2018.04.045
Abstract: Nanonizationhas been extensively investigated to increase theoral bioavailability of hydrophobicdrugsin general andantiretrovirals(ARVs)used inthe therapy of the human immunodeficiency virus (HIV) infection in particular. Weanticipatedthatin the caseofprotease inhibitors, a family of pH-dependent ARVsthatdisplay high aqueous solubility… read more here.
Keywords: drug; nanoparticle microparticle; clinically relevant; delivery system ... See more keywords
Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals.
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DOI: 10.1016/j.biotechadv.2018.08.004
Abstract: Application of bioactive phytochemicals in foods, supplements, and pharmaceuticals is often limited because of their poor solubility, stability, and bioavailability. Phytochemical oral delivery systems (PODS), consisting of phytochemical-loaded nanoparticles or microparticles, can overcome these challenges.… read more here.
Keywords: bioactivity; delivery systems; nanoparticle microparticle; advances nanoparticle ... See more keywords