Engineered Ferritin Nanoparticle Vaccines Enable Rapid Screening of Antibody Functionalisation to Boost Immune Responses.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202595
Abstract: Employing monoclonal antibodies to target vaccine antigens to different immune cells within lymph nodes where adaptive immunity is initiated can provide a mechanism to fine tune the magnitude of quality of immune responses. However, studying… read more here.
Keywords: engineered ferritin; ferritin nanoparticle; immune responses; rapid screening ... See more keywords
Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1415
Abstract: Traditionally, vaccines have been composed of live attenuated or killed microorganisms. Alternatively, individual protein subunits or other molecular components of the microorganism can serve as the antigen and trigger an antibody response by the immune… read more here.
Keywords: vaccines synergizing; rna nanoparticle; synergizing rna; nanoparticle ... See more keywords
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.10.043
Abstract: A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic. We describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice.… read more here.
Keywords: protein nanoparticle; nanoparticle; nanoparticle vaccines; sars cov ... See more keywords
Immunological basis for enhanced immunity of nanoparticle vaccines
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2019.1578216
Abstract: ABSTRACT Introduction: Immunization has been a remarkably successful public health intervention; however, new approaches to vaccine design are essential to counter existing and emerging infectious diseases which have defied traditional vaccination efforts to date. Nanoparticles… read more here.
Keywords: vaccines immunological; immunological basis; nanoparticle; immunity nanoparticle ... See more keywords
Design and immunological evaluation of two-component protein nanoparticle vaccines for East Coast fever
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1015840
Abstract: Nanoparticle vaccines usually prime stronger immune responses than soluble antigens. Within this class of subunit vaccines, the recent development of computationally designed self-assembling two-component protein nanoparticle scaffolds provides a powerful and versatile platform for displaying… read more here.
Keywords: nanoparticle; component protein; protein nanoparticle; two component ... See more keywords
Protein-Based Nanoparticle Vaccines for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222413445
Abstract: The pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has upended healthcare systems and economies around the world. Rapid understanding of the structural biology and pathogenesis of SARS-CoV-2 has allowed the development of… read more here.
Keywords: sars cov; nanoparticle vaccines; protein based; based nanoparticle ... See more keywords
Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Vaccines"
DOI: 10.3390/vaccines7030076
Abstract: The enormous sequence diversity between human immunodeficiency virus type 1 (HIV-1) strains poses a major roadblock for generating a broadly protective vaccine. Many experimental HIV-1 vaccine efforts are therefore aimed at eliciting broadly neutralizing antibodies… read more here.
Keywords: inducing hiv; hiv; neutralizing antibodies; hiv neutralizing ... See more keywords
A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9091041
Abstract: This work discusses the present-day limitations of current commercial Salmonella vaccines for broilers and layers and explores a novel approach towards poultry vaccination using biodegradable nanoparticle vaccines against Salmonella. With the increasing global population and… read more here.
Keywords: vaccines broilers; salmonella; novel approach; nanoparticle vaccines ... See more keywords