Developing Acid‐Responsive Glyco‐Nanoplatform Based Vaccines for Enhanced Cytotoxic T‐lymphocyte Responses Against Cancer and SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202105059
Abstract: Abstract Cytotoxic T‐lymphocytes (CTLs) are central for eliciting protective immunity against malignancies and infectious diseases. Here, for the first time, partially oxidized acetalated dextran nanoparticles (Ox‐AcDEX NPs) with an average diameter of 100 nm are… read more here.
Keywords: nanoplatform; acdex imine; acdex; acdex nps ... See more keywords
Hierarchical Precision Nanoplatform for Synergistic Radio‐Immunotherapy in Glioblastoma via Controllable P‐Selectin Targeting
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DOI: 10.1002/adfm.202516391
Abstract: The combination of radiotherapy and immune checkpoint blockade (ICB) therapy has demonstrated considerable efficacy in oncological treatment. However, the clinical PD‐L1 antibody (anti‐PD‐L1) for glioblastoma (GBM) imprecisely accumulated in intracranial radiotherapy target and is often… read more here.
Keywords: selectin; glioblastoma; hierarchical precision; nanoplatform ... See more keywords
Temperature-dependent CAT-like RGD-BPNS@SMFN Nanoplatform for PTT-PDT self-synergetic Tumor Phototherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102298
Abstract: Phototherapies such as photothermal therapy (PTT) and photodynamic therapy (PDT) are considered as alternatives for tumor remedies, because of their advantages of precise spatial orientation, minimally invasive and nonradiative operation. However, most of phototherapeutic agents… read more here.
Keywords: cat like; pdt self; ptt pdt; self synergetic ... See more keywords
An mTOR siRNA‐Loaded Spermidine/DNA Tetrahedron Nanoplatform with a Synergistic Anti‐Inflammatory Effect on Acute Lung Injury (Adv. Healthcare Mater. 11/2022)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200008
Abstract: Acute lung injury (ALI) is characterized by severe inflammation and damage to the lung air-blood barrier, resulting in respiratory function damage and life-threatening outcomes. Macrophage polarization plays an essential role in the occurrence, development, and… read more here.
Keywords: acute lung; dna; lung injury; anti inflammatory ... See more keywords
A Diketopyrrolopyrrole‐Based All‐in‐One Nanoplatform for Self‐Reinforcing Mild Photothermal Therapy Cascade Immunotherapy for Tumors
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DOI: 10.1002/adhm.202400766
Abstract: Mild photothermal therapy (PTT) has attracted attention for effectively avoiding the severe side effects associated with high‐temperature tumor ablation. However, its progress is hindered by the limited availability of high‐performance photothermal agents (PTAs) and the… read more here.
Keywords: diketopyrrolopyrrole based; mild photothermal; one nanoplatform; nanoplatform ... See more keywords
Eumelanin‐Enhanced Photothermal Disinfection of Contact Lenses Using a Sustainable Marine Nanoplatform Engineered with Electrospun Nanofibers
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DOI: 10.1002/adhm.202402431
Abstract: Bacterial keratitis (BK) is a severe eye infection commonly associated with Staphylococcus aureus (S. aureus), posing a significant risk to vision, especially among contact lens wearers. This research introduces a novel smart nanoplatform (deMS@cNF), developed… read more here.
Keywords: contact lenses; disinfection contact; photothermal disinfection; nanoplatform ... See more keywords
Duplex Responsive Nanoplatform with Cascade Targeting for Atherosclerosis Photoacoustic Diagnosis and Multichannel Combination Therapy
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DOI: 10.1002/adma.202300439
Abstract: The culprits of atherosclerosis are endothelial damage, local disorders of lipid metabolism, and progressive inflammation. Early atherosclerosis is typically difficult to diagnose in time due to the lack of obvious symptoms, thus missing the best… read more here.
Keywords: pmetpp mbt; duplex responsive; photoacoustic diagnosis; atherosclerosis ... See more keywords
Mitochondrial‐Targeted CS@KET/P780 Nanoplatform for Site‐Specific Delivery and High‐Efficiency Cancer Immunotherapy in Hepatocellular Carcinoma
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DOI: 10.1002/advs.202308027
Abstract: Hepatocellular carcinoma (HCC) is a form of malignancy with limited curative options available. To improve therapeutic outcomes, it is imperative to develop novel, potent therapeutic modalities. Ketoconazole (KET) has shown excellent therapeutic efficacy against HCC… read more here.
Keywords: ket p780; p780; ket; hepatocellular carcinoma ... See more keywords
Consumption of Endogenous Caspase‐3 Activates Molecular Theranostic Nanoplatform against Inflammation‐Induced Profibrotic Positive Feedback in Pulmonary Fibrosis
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DOI: 10.1002/advs.202412303
Abstract: The limited and backward diagnostic approaches elicit high mortality associated with pulmonary fibrosis (PF) because they fail to identify injury phase of PF. Developing a precisely theranostic nanoplatform presents a promising shortcut to reverse PF.… read more here.
Keywords: endogenous caspase; consumption endogenous; nanoplatform; pulmonary fibrosis ... See more keywords
Injured Myocardium‐Targeted Theranostic Nanoplatform for Multi‐Dimensional Immune‐Inflammation Regulation in Acute Myocardial Infarction
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DOI: 10.1002/advs.202414740
Abstract: Pyroptosis is a key mode of programmed cell death during the early stages following acute myocardial infarction (AMI), driving immune‐inflammatory responses. Cardiac resident macrophages (CRMs) are the primary mediators of cardiac immunity, and they serve… read more here.
Keywords: injured myocardium; inflammation; myocardial infarction; nanoplatform ... See more keywords
Near Infrared-Triggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200786
Abstract: Mild photothermal therapy (PTT, 50 °C). However, its therapeutic efficacy is limited owing to the hypoxic tumor environment and tumor thermoresistance owing to the overproduction of heat shock proteins (HSPs). Herein, a near-infrared (NIR)-triggered theranostic nanoplatform… read more here.
Keywords: hsp90; therapy; triggered theranostic; mild photothermal ... See more keywords