A Glucose/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202000897
Abstract: Fenton reaction-mediated chemodynamic therapy (CDT) can kill cancer cells via the conversion of H2 O2 to highly toxic HO•. However, problems such as insufficient H2 O2 levels in the tumor tissue and low Fenton reaction… read more here.
Keywords: oxygen; nanoreactor; chemodynamic therapy; therapy ... See more keywords
A Novel Cascade Nanoreactor Integrating Two-Dimensional Pd-Ru Nanozyme, Uricase and Red Blood Cell Membrane for Highly Efficient Hyperuricemia Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202103645
Abstract: Nanozyme-based cascade reaction has emerged as an effective strategy for disease treatment because of its high efficiency and low side effects. Herein, a new and highly active two-dimensional Pd-Ru nanozyme is prepared and then integrated… read more here.
Keywords: dimensional nanozyme; nanoreactor; uricase red; treatment ... See more keywords
Droplet Interface Bilayers as a Platform for a Spatially Segregated Nanoreactor
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.743
Abstract: Compartmentalisation is a defining feature of biological processes. Within eukaryotic cells, organelles serve as segregated microenvironments for specific biochemical processes. These microenvironments allow distinct chemical environments to be maintained within the cell and concentrate enzymes… read more here.
Keywords: spatially segregated; nanoreactor; interface bilayers; droplet interface ... See more keywords
Synthesis of mesoporous defective graphene-nanosheets in a space-confined self-assembled nanoreactor: Highly efficient capacitive energy storage
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2019.03.072
Abstract: Abstract Two-dimensional graphene-based materials are of great interest in electrochemical energy storage devices owing to their high theoretical specific capacitance; however, it is a big challenge to approach the theoretical limit. Here, we report a… read more here.
Keywords: energy storage; graphene nanosheets; energy; nanoreactor ... See more keywords
Selective Capture and in Situ Controllable Detection of d-Glucose in Cerebral Systems.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b05393
Abstract: To monitor d-glucose (Glu) in complex aqueous media with a high specificity, a conceptually new "selective capture and controllable detection" nanoreactor was explored. We designed and synthesized poly maleic anhydride-styrene-N-isopropylacrylamide-(4-aminophenyl) boronic acid [P(MAn-St-NIPAm-PBA)] to fabricate… read more here.
Keywords: controllable detection; nanoreactor; selective capture; glu ... See more keywords
Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c02634
Abstract: Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor elimination strategy for lung adenocarcinoma (ADC). However, the unsatisfactory Fenton reaction efficiency, strong intracellular antioxidant system, and insufficient lung drug accumulation limits… read more here.
Keywords: lung; tumor; nanoreactor; ferroptosis therapy ... See more keywords
Confined Cascade Metabolic Reprogramming Nanoreactor for Targeted Alcohol Detoxification and Alcoholic Liver Injury Management.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12075
Abstract: Alcoholic liver injury (ALI) is the leading cause of serious liver disease, whereas current treatments are mostly supportive and unable to metabolize alcohol directly. Here we report a metabolic reprogramming strategy for targeted alcohol detoxification… read more here.
Keywords: detoxification; nanoreactor; targeted alcohol; liver injury ... See more keywords
A Tumor-Targeted Cascade Nanoreactor Based on Metal-Organic-Frameworks for Synergistic Ferroptosis-Starvation Anticancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.9b07789
Abstract: Although ferroptosis therapy has been proved to be a promising strategy for cancer treatment, its efficacy still might be limited by insufficient H2O2 supply in tumor tissue. Herein, we designed a cancer cell membrane-cloaked cascade… read more here.
Keywords: nanoreactor; starvation; ferroptosis; therapy ... See more keywords
Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor
Sign Up to like & getrecommendations! Published in 2017 at "Polymer Chemistry"
DOI: 10.1039/c6py02155g
Abstract: Incorporation of the ATRP-catalyzing enzyme horseradish peroxidase (HRP) into the cavities of the group II chaperonin thermosome is demonstrated. The resulting nanoreactor was used to polymerize an acrylate under ARGET ATRP conditions. The confined space… read more here.
Keywords: nanoreactor; atom transfer; transfer radical; protein cage ... See more keywords
A cancer cell membrane-camouflaged nanoreactor for enhanced radiotherapy against cancer metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc07878a
Abstract: We report a cancer cell membrane-camouflaged nanoreactor based on a GOx decorated TiO2@MnO2 core-shell structure for enhanced radiotherapy against cancer metastasis. The nanoreactor could specifically target tumor tissues, catalytically oxidize glucose to generate H2O2, and… read more here.
Keywords: nanoreactor; cell membrane; membrane camouflaged; cancer cell ... See more keywords
Fabrication of a hierarchical nanoreactor based on COFs for cascade enzyme catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00269h
Abstract: A hierarchical nanoreactor based on covalent organic frameworks (COFs) was fabricated using polystyrene spheres (PSs) as a template. When applied in cascade catalysis, the nanoreactor significantly improved the catalytic activity of internal enzymes, and showed… read more here.
Keywords: catalysis; nanoreactor; fabrication hierarchical; nanoreactor based ... See more keywords