Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.
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DOI: 10.1016/j.bpj.2019.12.036
Abstract: Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dynamics underlying allostery. In contrast,… read more here.
Keywords: heterogeneity; timescale dynamics; nanosecond timescale; cooperativity ... See more keywords