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   Articles with "nanosuspension" as a keyword



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Comparative study on stabilizing ability of food protein, non‐ionic surfactant and anionic surfactant on BCS type II drug carvedilol loaded nanosuspension: Physicochemical and pharmacokinetic investigation

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recommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.08.005

Abstract: &NA; Carvedilol (CAR) in its pure state has low aqueous solubility and extremely poor bioavailability which largely limit its clinical application. The aim of the study is to improve the dissolution rate and the bioavailability… read more here.

Keywords: study; loaded nanosuspension; food protein; surfactant ... See more keywords
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Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation

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recommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2018.07.009

Abstract: &NA; Flurbiprofen (FB) is the one of the non‐steroidal anti‐inflammatory drugs (NSAIDs) which has low water solubility and dissolution. Nanosuspensions are promising drug delivery systems consisting pure drug particles to overcome poor water solubility issues.… read more here.

Keywords: water solubility; design experiment; solubility; vitro ... See more keywords
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Risk assessment and QbD based optimization of an Eprosartan mesylate nanosuspension: in-vitro characterization, PAMPA and in-vivo assessment.

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recommendations! Published in 2019 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2019.06.006

Abstract: Quality by design (QbD) principles were implemented to understand the product and process variables of sonoprecipitation technique, for preparation of eprosartan mesylate (EM) nanosuspension. Quality risk management approach was utilized to identify and assess high-risk… read more here.

Keywords: quality; qbd; mesylate nanosuspension; eprosartan mesylate ... See more keywords
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The impact of process parameters on carrier free paracetamol nanosuspension prepared using different stabilizers by antisolvent precipitation method

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recommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2017.10.001

Abstract: Abstract Poor aqueous solubility leading to poor oral bioavailability is a bottle neck in the development of many new drug candidates; particularly the BCS class II-IV drugs. These molecules are difficult to formulate using conventional… read more here.

Keywords: nanosuspension prepared; drug; different stabilizers; precipitation method ... See more keywords
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Fast disintegrating tablet of Doxazosin Mesylate nanosuspension: Preparation and characterization

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recommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2020.102210

Abstract: ABSTRACT Doxazosin Mesylate (DOX) is an antihypertensive drug which possesses poor water solubility and hence low bioavailability. The study objective is to prepare DOX fast disintegrating tablets as a new dosage form for geriatric patients.… read more here.

Keywords: disintegrating tablet; nanosuspension; fast disintegrating; doxazosin mesylate ... See more keywords
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Denatured food protein-coated nanosuspension: A promising approach for anticancer delivery of hydrophobic drug

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recommendations! Published in 2020 at "Journal of Molecular Liquids"

DOI: 10.1016/j.molliq.2020.112690

Abstract: Abstract The expenses of introducing new medications to the market are remarkably high; so, the repurposing of currently available drugs for new indications has become more convenient and a shortcut for drug development. Disulfiram has… read more here.

Keywords: microscopy; denatured food; delivery; drug ... See more keywords
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Telmisartan Nanosuspension for Inhaled Therapy of COVID-19 Lung Disease and Other Respiratory Infections

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recommendations! Published in 2022 at "Molecular Pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.2c00448

Abstract: Vaccine hesitancy and the occurrence of elusive variants necessitate further treatment options for coronavirus disease 2019 (COVID-19). Accumulated evidence indicates that clinically used hypertensive drugs, angiotensin receptor blockers (ARBs), may benefit patients by mitigating disease… read more here.

Keywords: respiratory infections; formulation; disease; lung ... See more keywords
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Nanoformulation of Curcuma longa Root Extract and Evaluation of Its Dissolution Potential

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c06258

Abstract: Medicinal plants have been widely used for therapeutic purposes for a long time, but they have been found to have some major issues such as low water solubility and bioavailability. In the present study, the… read more here.

Keywords: curcuma longa; dissolution; nanoformulation curcuma; dissolution potential ... See more keywords
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A quality-by-design study to develop Nifedipine nanosuspension: examining the relative impact of formulation variables, wet media milling process parameters and excipient variability on drug product quality attributes

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recommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"

DOI: 10.1080/03639045.2018.1503296

Abstract: Abstract Wet milling is a multifunctional and the most common method to prepare a drug nanosuspension for improving the bioavailability of poorly water soluble drugs. A suitable way of preparing a high drug-loaded nifedipine nanosuspension… read more here.

Keywords: quality; study; formulation; drug ... See more keywords

Quality by design-based optimization of formulation and process parameters for berberine nanosuspension for enhancing its dissolution rate, bioavailability, and cardioprotective activity.

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recommendations! Published in 2022 at "Journal of food biochemistry"

DOI: 10.1111/jfbc.14361

Abstract: Berberine (BER) possesses dissolution rate limited oral bioavailability. The present study deciphers the formulation of nanosuspension loaded with BER for enhancing its cardioprotective potential. The nanosuspension was prepared by a liquid antisolvent precipitation technique using… read more here.

Keywords: dissolution rate; bioavailability; rate; cardioprotective activity ... See more keywords

Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis.

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recommendations! Published in 2021 at "Journal of biomedical nanotechnology"

DOI: 10.1166/jbn.2021.3094

Abstract: Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short,… read more here.

Keywords: nanosuspension; tetramethylpyrazine; articular injection; tmp ... See more keywords