Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-021-07281-x
Abstract: Cysticercosis is a disease caused by the metacestode of the parasite Taenia solium (T. solium). In humans, the most severe complication of the disease is neurocysticercosis. The drug of choice to treat this disease is… read more here.
Keywords: cysticidal effect; taenia crassiceps; naphthoquinone; crassiceps cysticerci ... See more keywords
Electrogenerated superoxide anion: Hydroxylation of electroreducible substrates in aprotic solvent
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2016.08.023
Abstract: 2-Hydroxy-1,4-naphthoquinone, 2-hydroxy-3-methyl-1,4-naphthoquinone, 3-hydroxy-2,3-diphenylindan-1-one, 3,4-diphenyl-1H-isochromen-1-one and benzoic acid are prepared in good yield by radical coupling reaction of the electrogenerated radical anion of 1,4-naphthoquinone, 2-methyl-1,4-naphthoquinone, 2,3-diphenyl-1-H-inden-1-one or phenylacetylene respectively, with simultaneously electrogenerated superoxide anion. read more here.
Keywords: electrogenerated superoxide; anion; naphthoquinone; anion hydroxylation ... See more keywords
Dimerizations of 2-bromo-3-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone in tetra-n-butylammonium bromide
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DOI: 10.1016/j.tet.2019.130899
Abstract: Abstract 2-Bromo-3-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone are highly reactive species known to dimerize in various ways. The product obtained in the dimerization of each compound is primarily dependent upon the solvent used. Ionic liquids represent a new… read more here.
Keywords: tetra butylammonium; naphthoquinone; naphthoquinone methyl; bromo methyl ... See more keywords
Tetrabutylammonium iodide catalyzed hydroxylation of naphthoquinone derivatives with tert-butyl hydroperoxide as an oxidant
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.052
Abstract: Abstract We have developed an effective and environmentally benign procedure for the hydroxylation of naphthoquinone derivatives by using tetrabutylammonium iodide as a catalyst and tert-butyl hydroperoxide as an oxidant. This methodology provides a facile protocol… read more here.
Keywords: naphthoquinone; hydroxylation naphthoquinone; tetrabutylammonium iodide; naphthoquinone derivatives ... See more keywords
Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1366476
Abstract: Abstract Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9).… read more here.
Keywords: naphthoquinone; cell proliferation; anti cell; plumbago zeylanica ... See more keywords
Biosynthesis of Novel Naphthoquinone Derivatives in the Commonly-used Chassis Cells Saccharomyces cerevisiae and Escherichia coli
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DOI: 10.1134/s0003683821100124
Abstract: Naphthoquinones harboring 1,4-naphthoquinone pharmacophore are considered as privileged structures in medicinal chemistry. In pharmaceutical industry and fundamental research, polyketide naphthoquinones were widely produced by heterologous expression of polyketide synthases in microbial chassis cells, such as… read more here.
Keywords: cells saccharomyces; saccharomyces cerevisiae; used chassis; chassis cells ... See more keywords
Hybrid Molecules Containing Naphthoquinone and Quinolinedione Scaffolds as Antineoplastic Agents
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154948
Abstract: In recent decades, molecular hybridization has proven to be an efficient tool for obtaining new synthetic molecules to treat different diseases. Based on the core idea of covalently combining at least two pharmacophore fragments present… read more here.
Keywords: hybrid molecules; naphthoquinone quinolinedione; molecules containing; quinolinedione scaffolds ... See more keywords
New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061121
Abstract: To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in vitro on the epimastigote and trypomastigote forms of Trypanosoma… read more here.
Keywords: naphthoquinone; trypanosoma cruzi; naphthoquinone derivatives; trypanothione reductase ... See more keywords