Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.013
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) mediated kynurenine pathway of tryptophan degradation is identified as an appealing and novel target in immunotherapy for the treatment of cancer. In this study, a novel series of naphthoquinone derivatives were… read more here.
Keywords: design synthesis; biological evaluation; inhibitory activities; naphthoquinone derivatives ... See more keywords
Stereochemical assignments of rubiaquinones A–C, naphthoquinone derivatives from Rubia yunnanensis
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.10.051
Abstract: Three new naphthoquinone derivatives, rubiaquinones A-C (1-3), were isolated from the roots of Rubia yunnanensis. Rubiaquinone A (1) was a racemic naphthoquinone dimer consisting of a 1,4-dihydroxy-naphthalene and a 4-hydroxy-1,2-naphthoquinone moieties with a 2-oxo-propyl group.… read more here.
Keywords: stereochemical assignments; ecd spectra; naphthoquinone derivatives; rubiaquinones naphthoquinone ... See more keywords
Tetrabutylammonium iodide catalyzed hydroxylation of naphthoquinone derivatives with tert-butyl hydroperoxide as an oxidant
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.052
Abstract: Abstract We have developed an effective and environmentally benign procedure for the hydroxylation of naphthoquinone derivatives by using tetrabutylammonium iodide as a catalyst and tert-butyl hydroperoxide as an oxidant. This methodology provides a facile protocol… read more here.
Keywords: naphthoquinone; hydroxylation naphthoquinone; tetrabutylammonium iodide; naphthoquinone derivatives ... See more keywords
1,4‐Naphthoquinone derivatives potently suppress Candida albicans growth, inhibit formation of hyphae and show no toxicity toward zebrafish embryos
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000700
Abstract: Purpose. In this study, we applied various assays to find new activities of 1,4‐naphthoquinone derivatives for potential anti‐Candida albicans applications. Methodology. These assays determined (a) the antimicrobial effect on growth/cell multiplication in fungal cultures, (b)… read more here.
Keywords: microscopy; formation hyphae; naphthoquinone derivatives; zebrafish embryos ... See more keywords
Naphthoquinone Derivatives as Scaffold to Develop New Drugs for Tuberculosis Treatment
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00673
Abstract: Despite being a curable disease, tuberculosis (TB) remains a public health problem worldwide mainly due to lengthy treatment, as well as its toxic effects, TB/HIV co-infection and the emergence of resistant Mycobacterium tuberculosis strains. These… read more here.
Keywords: develop new; treatment; derivatives scaffold; naphthoquinone derivatives ... See more keywords
How Substitution Combines with Non-Covalent Interactions to Modulate 1,4-Naphthoquinone and Its Derivatives Molecular Features—Multifactor Studies
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910357
Abstract: Substitution is well-known to modulate the physico-chemical properties of molecules. In this study, a combined, multifactor approach was employed to determine a plethora of substitution patterns using –Br and –O-H in 1,4-naphthoquinone and its derivatives.… read more here.
Keywords: hydrogen; intramolecular hydrogen; group; naphthoquinone derivatives ... See more keywords
In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060687
Abstract: Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, for which there is no effective, low-cost, and low-toxicity treatment for the host. Naphthoquinones are ligands with redox properties involved in oxidative… read more here.
Keywords: molecular docking; naphthoquinone derivatives; activity; qsar molecular ... See more keywords
New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061121
Abstract: To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in vitro on the epimastigote and trypomastigote forms of Trypanosoma… read more here.
Keywords: naphthoquinone; trypanosoma cruzi; naphthoquinone derivatives; trypanothione reductase ... See more keywords
Two novel 1,4-naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species-mediated MAPK/Akt/STAT3 signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10500
Abstract: 1,4-Naphthoquinone derivatives have superior anticancer effects, but their use has been severely limited in clinical practice due to adverse side effects. To reduce the side effects and extend the anticancer effects of 1,4-naphthoquinone derivatives, 2-(butane-1-sulfinyl)-1,4-naphthoquinone… read more here.
Keywords: cycle arrest; gastric cancer; cell cycle; naphthoquinone derivatives ... See more keywords