Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins
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DOI: 10.1177/1934578x221133196
Abstract: A series of novel naphthoquinone-fused podophyllotoxins containing fluoro and trifluoromethyl substituents were synthesized in a medium with good yields using two different synthetic approaches: microwave-assisted four-component reactions of 2-hydroxy-1,4-naphthoquinone, tetronic acid, fluorinated arylaldehydes, and ammonium… read more here.
Keywords: naphthoquinone fused; novel naphthoquinone; fluoro trifluoromethyl; trifluoromethyl substituents ... See more keywords