REARRANGEMENT OF 3-CYANO-5 H -CHROMENO[2,3- b ]PYRIDINES TO 1,6-NAPHTHYRIDINE DERIVATIVES
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DOI: 10.1007/3991
Abstract: В сообщении описана перегруппировка замещенных 5 H -хромено[2,3- b ]пиридинов в оснoвной среде. В результате реализации механизма ANRORC и вращения пиридинового цикла происходит образование производных 1,6-нафтиридина с высокими выходами. read more here.
Keywords: pyridines naphthyridine; rearrangement cyano; chromeno pyridines; naphthyridine derivatives ... See more keywords
SYNTHESIS OF BENZO[ c ][1,7]NAPHTHYRIDINE DERIVATIVES
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DOI: 10.1007/5363
Abstract: Reactivity of 2-methyl-6-phenylbenzo[c][1,7]naphthyridine in alkylation, oxidation, and electrophilic substitution reactions has been studied. The reaction of 2-methyl-6-phenylbenzo[c][1,7]naphthyridines with POCl3 yielded the previously unknown 4-chloro-2-methyl-6-phenylbenzo[c]-[1,7]naphthyridine. Its dehalogenation and substitution of halogen by nitrogen and sulfur nucleophiles… read more here.
Keywords: naphthyridine derivatives; benzo naphthyridine; methyl phenylbenzo; synthesis benzo ... See more keywords
Synthesis of benzo[c][1,7]naphthyridine derivatives
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DOI: 10.1007/s10593-019-02581-8
Abstract: Reactivity of 2-methyl-6-phenylbenzo[c][1,7]naphthyridine in alkylation, oxidation, and electrophilic substitution reactions has been studied. The reaction of 2-methyl-6-phenylbenzo[c][1,7]naphthyridines with POCl3 yielded the previously unknown 4-chloro-2-methyl-6-phenylbenzo[c][1,7]naphthyridine. Its dehalogenation and substitution of halogen by nitrogen and sulfur nucleophiles… read more here.
Keywords: naphthyridine derivatives; benzo naphthyridine; methyl phenylbenzo; synthesis benzo ... See more keywords
Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators.
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DOI: 10.1021/acs.jmedchem.2c00414
Abstract: The discovery and characterization of novel naphthyridine derivatives with selective α5-GABAAR negative allosteric modulator (NAM) activity are disclosed. Utilizing a scaffold-hopping strategy, fused [6 + 6] bicyclic scaffolds were designed and synthesized. Among these, 1,6-naphthyridinones… read more here.
Keywords: selective gabaa; optimization naphthyridine; derivatives selective; multiparameter optimization ... See more keywords
Synthesis of the First Representatives of Thieno[3,2-c][1,7]naphthyridine Derivatives Based on 3-Amino-6-methyl-4-(2-thienyl) pyridin-2(1H)-one
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DOI: 10.1055/s-0037-1610445
Abstract: A one-pot method for obtaining novel thieno[3,2-c][1,7]naphthyridine derivatives based on the reaction of 3-amino-4-(thien-2-yl)pyridin-2(1H)-one with aromatic aldehydes in 80% phosphoric acid at 130 °C has been developed. The formation of the thieno[3,2-c][1,7]naphthyridine ring was due to… read more here.
Keywords: amino; pyridin one; naphthyridine derivatives; thieno naphthyridine ... See more keywords
Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
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DOI: 10.1515/chem-2019-0097
Abstract: Abstract A series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an in vitro evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds 3f,… read more here.
Keywords: naphthyridine derivatives; activity; cell line; novel naphthyridine ... See more keywords
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors
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DOI: 10.3390/molecules28041662
Abstract: In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (5), 1-indol-3-yl (8), and azocino[4,5-b]quinoline (10) derivatives, were synthesized and characterized herein for the first time.… read more here.
Keywords: synthesis novel; benzo naphthyridine; novel benzo; naphthyridine derivatives ... See more keywords