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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112174
Abstract: A series of 1,6-naphthyridinone-based MET kinase inhibitors bearing quinoline moiety in block A were designed and synthesized based on the structures of Cabozantinib and our reported compound IV. Extensive SAR and DMPK studies led to…
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Keywords:
naphthyridinone based;
kinase inhibitor;
met kinase;
based met ... See more keywords