Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
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DOI: 10.1021/acsmedchemlett.8b00013
Abstract: Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormonal… read more here.
Keywords: sodium phosphate; phosphate cotransporter; cotransporter napi2a; napi2a slc34a1 ... See more keywords