An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish
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DOI: 10.1371/journal.pone.0271707
Abstract: Although the increased risk of developing sporadic Alzheimer’s disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis… read more here.
Keywords: treatment napoe41; fragment; napoe41 151; amino terminal ... See more keywords