Children with Narcolepsy type 1 have increased T‐cell responses to orexins
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50908
Abstract: Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4+ and… read more here.
Keywords: type increased; children narcolepsy; narcolepsy type; orexins children ... See more keywords
CSF and serum ferritin levels in narcolepsy type 1 comorbid with restless legs syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51056
Abstract: To investigate whether cerebrospinal fluid (CSF) and serum ferritin levels differ between patients with narcolepsy type 1 (NT1) comorbid with restless legs syndrome (RLS) or periodic leg movements during sleep (PLMS), and patients with NT1… read more here.
Keywords: ferritin levels; narcolepsy type; comorbid; serum ferritin ... See more keywords
Reduced Numbers of Corticotropin‐Releasing Hormone Neurons in Narcolepsy Type 1
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26300
Abstract: Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post‐mortem brains, we observed 88% reduction in corticotropin‐releasing hormone (CRH)‐positive neurons in the paraventricular nucleus (PVN) and significantly less… read more here.
Keywords: releasing hormone; hormone; corticotropin releasing; numbers corticotropin ... See more keywords
Impact of COVID‐19 pandemic lockdown on narcolepsy type 1 management
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1955
Abstract: Narcolepsy type 1 (NT1) is a chronic rare hypersomnia of central origin requiring a combination of behavioral and pharmacological treatments. During the coronavirus disease 2019 (COVID‐19) pandemic, in Italy the population was forced into a… read more here.
Keywords: impact covid; management; narcolepsy type; pandemic lockdown ... See more keywords
A study on the optimal length of actigraphic recording in narcolepsy type 1
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Neurophysiology Practice"
DOI: 10.1016/j.cnp.2019.04.004
Abstract: Highlights • We examined the optimal length of actigraphic recording in patients with narcolepsy type 1.• No differences were detected between the mean values of 7-day and 14-day analyzed sets for the different sleep parameters.•… read more here.
Keywords: length actigraphic; optimal length; narcolepsy type; actigraphic recording ... See more keywords
Using actigraphy to assess sleep and wake rhythms of narcolepsy type 1 patients: a comparison with primary insomniacs and healthy controls.
Sign Up to like & getrecommendations! Published in 2018 at "Sleep medicine"
DOI: 10.1016/j.sleep.2018.07.024
Abstract: OBJECTIVE/BACKGROUND It has been shown that actigraphy may have a discriminant function (DS) for the diagnosis of narcolepsy type 1 patients (NT1), based on a combination of nighttime and daytime parameters. Here, we aimed to… read more here.
Keywords: type patients; healthy controls; actigraphy; narcolepsy type ... See more keywords
Csf and serum ferritin levels in narcolepsy type 1 comorbid with restless legs syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Sleep Medicine"
DOI: 10.1016/j.sleep.2019.11.067
Abstract: HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad,… read more here.
Keywords: ferritin levels; narcolepsy type; type comorbid; levels narcolepsy ... See more keywords
Comparative polysomnography parameters between narcolepsy type 1/type 2 and idiopathic hypersomnia: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep medicine reviews"
DOI: 10.1016/j.smrv.2022.101610
Abstract: A meta-analysis exploring polysomnography (PSG) differences between narcolepsy type 1 (NT1)/type 2 (NT2) and idiopathic hypersomnia (IH), particularly one that stratifies the analysis by IH with and without long sleep time (LST), could provide information… read more here.
Keywords: analysis; narcolepsy type; idiopathic hypersomnia; polysomnography ... See more keywords
Serum N-Glycan Profiling of Patients with Narcolepsy Type 1 Using LC-MS/MS
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DOI: 10.1021/acsomega.4c01593
Abstract: The neurological condition known as narcolepsy type 1 (NT1) is an uncommon condition marked by extreme daytime sleepiness, cataplexy, sleep paralysis, hallucinations, disrupted nocturnal sleep, and low or undetectable levels of orexin in the CSF… read more here.
Keywords: glycan biomarkers; glycan profiling; profiling patients; narcolepsy type ... See more keywords
0769 FDG-PET Imaging In Narcolepsy Type 1, Idiopathic Hypersomnia, And Non-Sleepy Controls
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.765
Abstract: Functional imaging of narcolepsy type 1 (NT1) has shown disparate results, with evidence for both regional hyper- and hypo-metabolism. A FDG-PET study of idiopathic hypersomnia (IH) demonstrated regional hypermetabolism within the salience network. Patients with… read more here.
Keywords: hypersomnia; fdg pet; fdg; narcolepsy type ... See more keywords
Narcolepsy type 1: what have we learned from genetics?
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa099
Abstract: Abstract Type-1 narcolepsy is a severe neurological disorder with distinct characteristic of loss of hypocretin neurotransmitter. Genetic analysis in type-1 narcolepsy have revealed a unique signal pointing toward autoimmune, rather than psychiatric origin. While type-1… read more here.
Keywords: genetics; narcolepsy type; type learned; type ... See more keywords