Small-molecule inhibition of the C. difficile FAS-II enzyme, FabK, results in selective activity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00293
Abstract: Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high and multiple recurrences are not uncommon. Causes include treatments… read more here.
Keywords: narrow spectrum; fabk; inhibition; small molecule ... See more keywords
Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25407-7
Abstract: The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent antibacterial properties that was engineered… read more here.
Keywords: narrow spectrum; nitrothiophene carboxamides; mechanism; carboxamides novel ... See more keywords
Ridinilazole: a novel, narrow-spectrum antimicrobial agent targeting Clostridium (Clostridioides) difficile.
Sign Up to like & getrecommendations! Published in 2022 at "Letters in applied microbiology"
DOI: 10.1111/lam.13664
Abstract: Clostridium (Clostridioides) difficile infection (CDI) remains an urgent threat to patients in health systems worldwide. Recurrent CDI occurs in up to 30% of cases due to sustained dysbiosis of the gut microbiota which normally protects… read more here.
Keywords: clostridium clostridioides; narrow spectrum; treatment; cdi ... See more keywords
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Cell"
DOI: 10.15698/mic2022.07.780
Abstract: Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems. Broad-spectrum antibiotics eradicate the normal gut microbiome, killing protective commensal bacteria and increasing… read more here.
Keywords: narrow spectrum; designing narrow; spectrum; bacterial pathogens ... See more keywords
Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.901911
Abstract: Treatment for moderate-to-severe acne vulgaris relies on prolonged use of oral tetracycline-class antibiotics; however, these broad-spectrum antibiotics are often associated with off-target effects and negative gastrointestinal sequelae. Sarecycline is a narrow-spectrum antibiotic treatment option. Here,… read more here.
Keywords: spectrum antibiotic; microbiota; gut microbiota; narrow spectrum ... See more keywords
Under-utilization of Narrow-Spectrum Antibiotics in the Ambulatory Management of Pediatric UTI: A Single-Center Experience
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.675759
Abstract: Objective: There are urinary tract infection (UTI) guidelines for treatment of patients read more here.
Keywords: narrow spectrum; pediatric uti; spectrum antibiotics; management pediatric ... See more keywords
Narrow-Spectrum Antibacterial Agents—Benefits and Challenges
Sign Up to like & getrecommendations! Published in 2020 at "Antibiotics"
DOI: 10.3390/antibiotics9070418
Abstract: The number of antibacterial agents in clinical and preclinical development possessing activity against a narrow spectrum of bacterial pathogens is increasing, with many of them being nontraditional products. The key value proposition hinges on sparing… read more here.
Keywords: narrow spectrum; benefits challenges; antibacterial agents; agents benefits ... See more keywords