Imidazole‐Rich, Four‐Armed Host‐Defense Peptidomimetics as Promising Narrow‐Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400664
Abstract: The development of narrow‐spectrum antimicrobial agents is paramount for swiftly eradicating pathogenic bacteria, mitigating the onset of drug resistance, and preserving the homeostasis of bacterial microbiota in tissues. Owing to the limited affinity between the… read more here.
Keywords: four armed; armed host; host defense; imidazole rich ... See more keywords
Effects of Broad-Spectrum Antimicrobials on Patients with Community-Acquired Pneumonia with Low Risk for Drug-Resistant Pathogens: Historical Cohort Study in Japan
Sign Up to like & getrecommendations! Published in 2025 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-025-01142-1
Abstract: Broad-spectrum antimicrobials are commonly administered for community-acquired pneumonia (CAP); however, unnecessary administration may cause adverse events and poor outcomes. This study aimed to understand the impact of broad-spectrum anti-pseudomonal β-lactam use on clinical outcomes and… read more here.
Keywords: broad spectrum; narrow spectrum; spectrum; spectrum group ... See more keywords
Small-molecule inhibition of the C. difficile FAS-II enzyme, FabK, results in selective activity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00293
Abstract: Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high and multiple recurrences are not uncommon. Causes include treatments… read more here.
Keywords: narrow spectrum; fabk; inhibition; small molecule ... See more keywords
Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25407-7
Abstract: The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent antibacterial properties that was engineered… read more here.
Keywords: narrow spectrum; nitrothiophene carboxamides; mechanism; carboxamides novel ... See more keywords
P-1142. Evaluating Ambulatory Antibiotic Prescribing for Respiratory Infections at a Pediatric Institution
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1329
Abstract: Abstract Background Over 85% of antibiotic prescribing occurs in outpatient settings such as emergency departments (ED), urgent care centers (UCC), and primary care clinics (PCC); almost half of antibiotics are prescribed for respiratory infections (RI).… read more here.
Keywords: respiratory infections; narrow spectrum; possible bacterial; antibiotic prescribing ... See more keywords
Ridinilazole: a novel, narrow-spectrum antimicrobial agent targeting Clostridium (Clostridioides) difficile.
Sign Up to like & getrecommendations! Published in 2022 at "Letters in applied microbiology"
DOI: 10.1111/lam.13664
Abstract: Clostridium (Clostridioides) difficile infection (CDI) remains an urgent threat to patients in health systems worldwide. Recurrent CDI occurs in up to 30% of cases due to sustained dysbiosis of the gut microbiota which normally protects… read more here.
Keywords: clostridium clostridioides; narrow spectrum; treatment; cdi ... See more keywords
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Cell"
DOI: 10.15698/mic2022.07.780
Abstract: Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems. Broad-spectrum antibiotics eradicate the normal gut microbiome, killing protective commensal bacteria and increasing… read more here.
Keywords: narrow spectrum; designing narrow; spectrum; bacterial pathogens ... See more keywords
Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.901911
Abstract: Treatment for moderate-to-severe acne vulgaris relies on prolonged use of oral tetracycline-class antibiotics; however, these broad-spectrum antibiotics are often associated with off-target effects and negative gastrointestinal sequelae. Sarecycline is a narrow-spectrum antibiotic treatment option. Here,… read more here.
Keywords: spectrum antibiotic; microbiota; gut microbiota; narrow spectrum ... See more keywords
Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2024.1487829
Abstract: Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates the potential of two benzofuroxan (Bfx) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico,… read more here.
Keywords: treatment; benzofuroxan; narrow spectrum; silico vitro ... See more keywords
Under-utilization of Narrow-Spectrum Antibiotics in the Ambulatory Management of Pediatric UTI: A Single-Center Experience
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.675759
Abstract: Objective: There are urinary tract infection (UTI) guidelines for treatment of patients read more here.
Keywords: narrow spectrum; pediatric uti; spectrum antibiotics; management pediatric ... See more keywords
Thanatin and vinyl sulfide analogues as narrow spectrum antimicrobial peptides that synergise with polymyxin B
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1487338
Abstract: Thanatin is a β-hairpin antimicrobial peptide cyclised by a single disulfide bond that has shown potent broad-spectrum activity towards bacterial and fungal pathogens. Towards Gram-negative species, thanatin acts both by forming trans-membranal pores and inhibiting… read more here.
Keywords: narrow spectrum; thanatin vinyl; polymyxin; vinyl sulfide ... See more keywords