Application of the QbD-based approach in the early development of liposomes for nasal administration.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.021
Abstract: In this study, authors adapt the Quality by Design (QbD) concept as well as the Risk Assessment (RA) method to the early development phase of a new nano-sized liposomal formulation for nasal administration with brain… read more here.
Keywords: early development; nasal administration; development; application qbd ... See more keywords
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220272120
Abstract: Significance Activated T cells play an important role in the complications following COVID-19 infection. Anti-CD3 monoclonal antibody (mAb) binds to the T cell receptor and dampens inflammation by modulating T cell function. We show here… read more here.
Keywords: anti cd3; mab foralumab; cd3 mab; nasal administration ... See more keywords
Implications of nasal delivery of bromelain on its pharmacokinetics, tissue distribution and pharmacodynamic profile—A preclinical study
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277849
Abstract: Asthma is a polygenic chronic inflammatory respiratory disease devastating the quality of life and state economies. Therefore, utilization of natural products as a therapeutic approach has attained wider consideration for development of novel drugs for… read more here.
Keywords: administration; nasal administration; bromelain; tissue distribution ... See more keywords
Oral and Intra-nasal Administration of Nanoparticles in the Cerebral Ischemia Treatment in Animal Experiments: Considering its Advantages and Disadvantages
Sign Up to like & getrecommendations! Published in 2019 at "Current Clinical Pharmacology"
DOI: 10.2174/1574884714666190704115345
Abstract: Background Over the past few decades, nanotechnology has dramatically advanced; from the precise strategies of synthesizing modern nanostructures to methods of entry into the body. Using nanotechnology in diagnosis, drug delivery, determining signaling pathways, and… read more here.
Keywords: oral intra; intra nasal; nasal administration; ischemia treatment ... See more keywords
Ex-Vivo and In-Vivo Assessment of Cyclamen europaeum Extract After Nasal Administration
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics11090426
Abstract: Rhinosinusitis is a prevalent disorder with a severe impact on the health-related quality of life. Saponins of Cyclamen europaeum exert a clinically proven curative effect on rhinosinusitis symptoms when instilled into the nasal cavity, however,… read more here.
Keywords: administration; assessment cyclamen; nasal administration; vivo vivo ... See more keywords
Different Methods and Formulations of Drugs and Vaccines for Nasal Administration
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DOI: 10.3390/pharmaceutics14051073
Abstract: Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some… read more here.
Keywords: administration; nasal administration; nasal drug; drug delivery ... See more keywords
Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020317
Abstract: Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form… read more here.
Keywords: cyclodextrin; spray dried; nasal administration; beta cyclodextrin ... See more keywords