Transcriptome sequencing reveals altered ciliogenesis under hypoxia in nasal epithelial cells from chronic rhinosinusitis with nasal polyps
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12168
Abstract: Abstract Background Hypoxia is considered a key factor in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the specific mechanism driving polypogenesis under hypoxic conditions is unclear. This study aimed to explore hypoxia‐induced… read more here.
Keywords: ciliogenesis; nasal polyps; nasal epithelial; hypoxia ... See more keywords
ADRB2 suppresses IL-13-induced allergic rhinitis inflammatory cytokine regulated by miR-15a-5p
Sign Up to like & getrecommendations! Published in 2019 at "Human Cell"
DOI: 10.1007/s13577-019-00259-z
Abstract: Abstract Allergic rhinitis (AR) is a common hypersensitive disease that troubles patients a lot. Nasal epithelial cells (NECs), as the outmost protection of inhalation, play an important role in AR allergic response. Adrenoceptor beta 2… read more here.
Keywords: allergic rhinitis; regulated mir; nasal epithelial; mir 15a ... See more keywords
Interleukin‐33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2016.10.010
Abstract: HighlightsIL‐33 was upregulated in nasal polyps of eosinophilic chronic rhinosinusitis.IL‐33 increase MUC5AC gene and MUC5AC protein in primary human nasal epithelial cell.IL‐33 induces goblet cell hyperplasia in primary human nasal epithelial cell. Abstract We investigated… read more here.
Keywords: nasal epithelial; human nasal; cell hyperplasia; goblet cell ... See more keywords
FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0129-x
Abstract: The nasal cavity displays immune tolerance to commensal bacteria under homeostatic conditions, which is rapidly converted to a pro-inflammatory response upon infection. Yet, the factors that control this conversion are still largely unknown. Here, we… read more here.
Keywords: epithelial cells; tolerance; human nasal; riii stimulation ... See more keywords
Choosing the Right Differentiation Medium to Develop Mucociliary Phenotype of Primary Nasal Epithelial Cells In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63922-8
Abstract: In vitro differentiation of airway epithelium is of interest for respiratory tissue engineering and studying airway diseases. Both applications benefit from the use of primary cells to maintain a mucociliated phenotype and thus physiological functionality.… read more here.
Keywords: phenotype; epithelial cells; nasal epithelial; growth factor ... See more keywords
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218083120
Abstract: Significance All respiratory viruses, including human coronaviruses (HCoVs), enter and establish a primary infection in the nasal epithelium. Primary nasal epithelial cells cultured at air–liquid interface (ALI) closely resemble the in vivo nasal epithelium and… read more here.
Keywords: primary nasal; infection; nasal epithelial; among lethal ... See more keywords
5-Oxo-ETE from Nasal Epithelial Cells Upregulates Eosinophil Cation Protein by Eosinophils in Nasal Polyps in vitro
Sign Up to like & getrecommendations! Published in 2018 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000489819
Abstract: Background: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant and activator that is synthesized not only in inflammatory cells but also in bronchial epithelial cells. The purpose of this study is to clarify whether 5-oxo-ETE… read more here.
Keywords: epithelial cells; eosinophils nasal; cation protein; eosinophil cation ... See more keywords
Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1225-5
Abstract: Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to study immune responses in pregnancy. pNECs were… read more here.
Keywords: epithelial cells; immune responses; pregnant women; pnecs ... See more keywords
Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001728
Abstract: Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2… read more here.
Keywords: ancestral sars; omicron; nasal epithelial; epithelial cells ... See more keywords
Characterisation of morphological differences in well-differentiated nasal epithelial cell cultures from preterm and term infants at birth and one-year
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0201328
Abstract: Background Innate immune responses of airway epithelium are important defences against respiratory pathogens and allergens. Newborn infants are at greater risk of severe respiratory infections compared to older infants, while premature infants are at greater… read more here.
Keywords: term; term preterm; one year; nasal epithelial ... See more keywords
An evaluation of ketoprofen as an intranasal anti-inflammatory agent.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202212_30474
Abstract: OBJECTIVE The objective of the study was to evaluate the effect of ketoprofen when locally applied to tissue-cultured nasal epithelium. MATERIALS AND METHODS Healthy primary nasal epithelial cells were grown in a tissue culture medium.… read more here.
Keywords: ketoprofen; evaluation ketoprofen; ketoprofen intranasal; nasal epithelial ... See more keywords