A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.05.012
Abstract: Respiratory syncytial virus infection was examined using a human nasal epithelial cell model. Maximum levels of shed-virus were produced at between 3 and 5 days post-infection (dpi), and the infectivity of the shed-virus was stable… read more here.
Keywords: nasal epithelium; respiratory syncytial; response; progeny virus ... See more keywords
A 3D-printed microfluidic platform for simulating the effects of CPAP on the nasal epithelium
Sign Up to like & getrecommendations! Published in 2021 at "Biofabrication"
DOI: 10.1088/1758-5090/abe4c1
Abstract: Obstructive sleep apnea (OSA) is a chronic disorder that involves a decrease or complete cessation of airflow during sleep. It occurs when the muscles supporting the soft tissues in the throat relax during sleep, causing… read more here.
Keywords: microfluidic platform; effects cpap; nasal epithelium; treatment ... See more keywords
Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.01944-22
Abstract: An in vitro model of the nasal epithelium is imperative for understanding cell biology and virus-host interaction in the human upper respiratory tract. Here we report an organoid culture system of the nasal epithelium. ABSTRACT… read more here.
Keywords: nasal organoids; epithelium; upper respiratory; nasal epithelium ... See more keywords
Interleukin-17C protects nasal epithelium from pseudomonas aeruginosa infection.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2018-0377oc
Abstract: Recent studies show that Interleukin-17 (IL-17) family cytokines are directly involved in host immune responses against respiratory bacterial infection and in particular, IL-17C is highly induced in bacterial infected respiratory epithelium. Our study is focused… read more here.
Keywords: pseudomonas aeruginosa; infection; nhne cells; pao1 ... See more keywords
Interleukin-13 Alters Tight Junction Proteins Expression Thereby Compromising Barrier Function and Dampens Rhinovirus Induced Immune Responses in Nasal Epithelium
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.572749
Abstract: Tight junctions (TJs) are intercellular structures which are essential for epithelial barrier function and play an important role in antimicrobial defense. Epithelium dysfunction and type-2-skewed inflammation are two main pathological phenomena of chronic rhinosinusitis with… read more here.
Keywords: nasal epithelium; interleukin alters; infection; barrier function ... See more keywords
Host Antiviral Response Suppresses Ciliogenesis and Motile Ciliary Functions in the Nasal Epithelium
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.581340
Abstract: Background Respiratory viral infections are one of the main drivers of development and exacerbation for chronic airway inflammatory diseases. Increased viral susceptibility and impaired mucociliary clearance are often associated with chronic airway inflammatory diseases and… read more here.
Keywords: functions nasal; nasal epithelium; response; infection ... See more keywords
A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02514
Abstract: Background: We established an in vitro co-culture model involving H3N2-infection of human nasal epithelium with peripheral blood mononuclear cells (PBMC) to investigate their cross-talk during early H3N2 infection. Methods: Nasal epithelium was differentiated from human… read more here.
Keywords: nasal epithelium; human nasal; epithelium; infection ... See more keywords
Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12863
Abstract: Ubiquitin-specific peptidase 25 (USP25) is a key deubiquitylase belonging to the USP superfamily that is primarily involved in inflammation and the immune response. Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine that is regarded as… read more here.
Keywords: signaling nasal; tslp signaling; protein expression; expression ... See more keywords