Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2019.1189
Abstract: Importance Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. Objective To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with… read more here.
Keywords: relapse; treatment; nasal spray; oral antidepressant ... See more keywords
Consistent safety and tolerability of Valtoco® (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long‐term, open‐label, repeat‐dose safety study
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia Open"
DOI: 10.1002/epi4.12494
Abstract: Need for rescue therapy differs among patients with seizure clusters. Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age. This analysis used interim data from a phase… read more here.
Keywords: patients seizure; diazepam nasal; safety; seizure clusters ... See more keywords
Nasal spray of an IgM‐like ACE2 fusion protein HH‐120 accelerates SARS‐CoV‐2 clearance: A single‐center propensity score‐matched cohort study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28805
Abstract: HH‐120, a recently developed IgM‐like ACE2 fusion protein with broad‐spectrum neutralizing activity against all ACE2‐utilizing coronaviruses, has been developed as a nasal spray for use as an early treatment agent to reduce disease progression and… read more here.
Keywords: clearance; 120 nasal; sars cov; nasal spray ... See more keywords
Esketamine nasal spray for treatment‐resistant depression
Sign Up to like & getrecommendations! Published in 2020 at "Prescriber"
DOI: 10.1002/psb.1845
Abstract: A nasal spray formulation of esketamine (Spravato) was licensed as adjunctive therapy for the management of adults with treatment‐resistant major depression in December. This article discusses the properties, clinical trial efficacy and adverse effects of… read more here.
Keywords: treatment; treatment resistant; esketamine; nasal spray ... See more keywords
In vitro Assessment of an Idealized Nose for Nasal Spray Testing: Comparison with Regional Deposition in Realistic Nasal Replicas.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119341
Abstract: An idealized nasal replica that mimics average regional deposition of nasal spray pump droplets in human nasal airways would potentially be useful in expediting the development of nasal spray products. The aim of this study… read more here.
Keywords: deposition; regional deposition; replicas; nasal spray ... See more keywords
Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.04.082
Abstract: BACKGROUND There is no nonparenteral medication for the rapid termination of paroxysmal supraventricular tachycardia. OBJECTIVES The purpose of this study was to assess the efficacy and safety of etripamil nasal spray, a short-acting calcium-channel blocker,… read more here.
Keywords: supraventricular tachycardia; etripamil; etripamil nasal; conversion ... See more keywords
Appraising esketamine nasal spray for the management of treatment-resistant depression in adults: Number needed to treat, number needed to harm, and likelihood to be helped or harmed.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.03.106
Abstract: INTRODUCTION This post hoc study assessed the evidence-base for esketamine nasal spray for management of treatment-resistant depression (TRD) using number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or… read more here.
Keywords: nasal spray; esketamine nasal; esketamine; number needed ... See more keywords
Treatment Response to Esketamine Nasal Spray in Patients With Major Depressive Disorder and Acute Suicidal Ideation or Behavior Without Evidence of Early Response: A Pooled Post Hoc Analysis of ASPIRE.
Sign Up to like & getrecommendations! Published in 2022 at "CNS spectrums"
DOI: 10.1017/s1092852922000931
Abstract: Objective. To assess the likelihood of attaining response/remission of depressive symptoms withesketamine nasalspray (ESK) plusstandard ofcare (SoC) vsplacebo nasal spray (PBO)plus SoCat 4weeks in patients withmajor depressive disorder and active suicidal ideation withintent (MDSI) without… read more here.
Keywords: plus soc; pbo; response remission; remission ... See more keywords
Primary spray breakup from a nasal spray atomizer using volume of fluid to discrete phase model
Sign Up to like & getrecommendations! Published in 2023 at "Physics of Fluids"
DOI: 10.1063/5.0150890
Abstract: Spray atomization process involves complex multi-phase phenomena. Abundant literature and validation of spray modeling for industrial applications like fuel injection in internal combustion and turbine jet engines are available. However, only a handful of studies,… read more here.
Keywords: spray; phase; volume fluid; discrete phase ... See more keywords
A randomized controlled trial comparing a xyloglucan-based nasal spray with saline in adults with symptoms of rhinosinusitis
Sign Up to like & getrecommendations! Published in 2018 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2017.1341402
Abstract: Abstract Background: This study assessed the efficacy, safety and tolerability of a xyloglucan-based nasal spray in the treatment of symptoms of rhinosinusitis. Methodology: In this randomized, double-blind study, 40 patients with itching, nasal congestion or… read more here.
Keywords: xyloglucan based; spray; based nasal; saline ... See more keywords
Etripamil nasal spray: an investigational agent for the rapid termination of paroxysmal supraventricular tachycardia (SVT)
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2020.1703180
Abstract: ABSTRACT Introduction: Paroxysmal supraventricular tachycardia (SVT) can be very bothersome and may potentially lead to considerable health-care utilization. Non-parenteral medication is currently unavailable for the rapid termination of paroxysmal SVT. However, an intranasal spray formulation… read more here.
Keywords: supraventricular tachycardia; etripamil nasal; paroxysmal supraventricular; tachycardia svt ... See more keywords