Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.022
Abstract: The ribosome-associated quality control (RQC) pathway degrades nascent chains (NCs) arising from interrupted translation. First, recycling factors split stalled ribosomes, yielding NC-tRNA/60S ribosome-nascent chain complexes (60S RNCs). 60S RNCs associate with NEMF, which recruits the… read more here.
Keywords: nascent; nascent chains; non ubiquitinated; 60s rncs ... See more keywords
Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
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DOI: 10.1038/s41467-019-10647-6
Abstract: Protein folding can begin co-translationally. Due to the difference in timescale between folding and synthesis, co-translational folding is thought to occur at equilibrium for fast-folding domains. In this scenario, the folding kinetics of stalled ribosome-bound… read more here.
Keywords: ribosome bound; nascent; time; equilibrium ... See more keywords