Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2021.106937
Abstract: NMR measurements of cross-correlated nuclear spin relaxation provide powerful probes of polypeptide dynamics and rotational diffusion, free from contributions due to chemical exchange or interactions with external spins. Here, we report on the development of… read more here.
Keywords: optimal design; chain; nascent chain; ribosome nascent ... See more keywords
Ribosome-associated quality-control mechanisms from bacteria to humans.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.03.038
Abstract: Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides produced by interrupted translation. Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, which sense large ribosomal… read more here.
Keywords: associated quality; quality control; nascent chain; ribosome associated ... See more keywords
Mechanochemistry in Translation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00260
Abstract: As the influence of translation rates on protein folding and function has come to light, the mechanisms by which translation speed is modulated have become an important issue. One mechanism entails the generation of force… read more here.
Keywords: nascent chain; generate forces; translation; mechanochemistry translation ... See more keywords