Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.022
Abstract: The ribosome-associated quality control (RQC) pathway degrades nascent chains (NCs) arising from interrupted translation. First, recycling factors split stalled ribosomes, yielding NC-tRNA/60S ribosome-nascent chain complexes (60S RNCs). 60S RNCs associate with NEMF, which recruits the… read more here.
Keywords: nascent; nascent chains; non ubiquitinated; 60s rncs ... See more keywords
Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
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DOI: 10.1038/s41467-019-10647-6
Abstract: Protein folding can begin co-translationally. Due to the difference in timescale between folding and synthesis, co-translational folding is thought to occur at equilibrium for fast-folding domains. In this scenario, the folding kinetics of stalled ribosome-bound… read more here.
Keywords: ribosome bound; nascent; time; equilibrium ... See more keywords
Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
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DOI: 10.1038/s41586-018-0022-5
Abstract: Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain sequences1, 2. Some stalls in budding yeast are sensed by the GTPase Hbs1,… read more here.
Keywords: nascent chains; trna hydrolase; stalled ribosomes; peptidyl trna ... See more keywords