The BRCA2 and CDKN1A‐interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA
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DOI: 10.1002/1873-3468.14406
Abstract: DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The… read more here.
Keywords: bccip; dna; nascent dna; replication ... See more keywords
Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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DOI: 10.1016/j.celrep.2019.05.002
Abstract: Summary RIF1 is a multifunctional protein implicated in controlling DNA replication and repair. Here, we show that human RIF1 protects nascent DNA from over-degradation at stalled replication forks. The major nuclease resecting nascent DNA in… read more here.
Keywords: degradation; rif1; dna; nascent dna ... See more keywords