RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32651
Abstract: Background and Aims: Nonalcoholic fatty liver disease and its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there are no approved therapies for the treatment of NASH.… read more here.
Keywords: ddx5; mtorc1; dead box; nonalcoholic steatohepatitis ... See more keywords
Liver Transplantation and Bariatric Surgery: Timing and Outcomes
Sign Up to like & getrecommendations! Published in 2018 at "Liver Transplantation"
DOI: 10.1002/lt.25303
Abstract: Nonalcoholic steatohepatitis (NASH) is projected to become the leading indication for liver transplantation (LT) in the next decade in the United States. Strategies to treat the underlying etiology of NASH, which is almost always obesity,… read more here.
Keywords: transplantation; liver transplantation; bariatric surgery; nash ... See more keywords
Liver Transplantation for Nonalcoholic Steatohepatitis in the US: Temporal Trends and Outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4684-x
Abstract: AbstractBackground and AimsNonalcoholic steatohepatitis (NASH) is a rapidly growing etiology of end-stage liver disease in the US. Temporal trends and outcomes in NASH-related liver transplantation (LT) in the US were studied.MethodsA retrospective cohort study utilizing… read more here.
Keywords: temporal trends; ald; etiology; trends outcomes ... See more keywords
Is That Possible to Stop or Cease the NASH to Turn into HCC?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-017-9961-6
Abstract: We do not exactly know this because the etiopathogenesis of non-alcoholic steatohepatitis (NASH) is not completely known. But this progression can slow down by taking certain measures. Non-alcoholic fatty liver disease (NAFLD) is present in… read more here.
Keywords: hcc; cirrhosis; disease; liver ... See more keywords
Myeloid deficiency of CCN3 exacerbates liver injury in a mouse model of nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0432-4
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat accumulates in the liver of patients without a prior history of alcohol abuse. The most severe form, nonalcoholic steatohepatitis (NASH), often leads to hepatic… read more here.
Keywords: fatty liver; disease; nash; liver injury ... See more keywords
Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119823
Abstract: Non-alcoholic steatohepatitis (NASH) is associated with liver fibrosis and cirrhosis, which eventually leads to hepatocellular carcinoma. Although several animal models were developed to understand the mechanisms of NASH pathogenesis and progression, it remains obscure. A… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; liver; steatohepatitis nash ... See more keywords
Familial non-alcoholic steatohepatitis leading to hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109054
Abstract: BACKGROUND AND AIMS Non-alcoholic steatohepatitis (NASH) has been associated with fibrosis that may progress to cirrhosis. The purpose of this study was to examine hepatocytes and perisinusoidal cells in liver biopsies of 3 families (3… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; liver biopsies; nash ... See more keywords
Curcumin ameliorates liver damage and progression of NASH in NASH‐HCC mouse model possibly by modulating HMGB1‐NF‐&kgr;B translocation
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.01.016
Abstract: &NA; Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as antitumor, anti‐inflammatory, anti‐cancer and so on. The study aimed to investigate the underlying mechanisms of curcumin to protect liver damage and… read more here.
Keywords: hmgb1 kgr; kgr translocation; model; nash ... See more keywords
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.10.010
Abstract: Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. Methods GAS6/TAM signaling was analyzed in… read more here.
Keywords: gas6; gas6 tam; hfd fed; fed mice ... See more keywords
From the Editor's desk....: April 2018.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.01.013
Abstract: Xu et al., 2018. Hepatic pyroptosis in NASH Hepatic pyroptosis in NASH There is a clear need to identify molecular mechanisms of nonalcoholic steatohepatitis (NASH) to develop novel targeted therapies. Pyroptosis is a highly inflammatory… read more here.
Keywords: april 2018; pyroptosis; nash; editor desk ... See more keywords
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119403
Abstract: AIMS Many dietary NASH models require a long duration to establish (4-6 months). Chronic intermittent hypoxia (CIH), a cardinal hallmark of obstructive sleep apnea (OSA), may accelerate the progression of pediatric nonalcoholic fatty liver disease (NAFLD).… read more here.
Keywords: rapid juvenile; diet induced; model; nash ... See more keywords