Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98806-y
Abstract: Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components and represents a leading cause of morbidity and mortality worldwide. Previous studies of nonalcoholic steatohepatitis (NASH) with fibrosis were largely… read more here.
Keywords: single cell; fibrosis; bulk; nash fibrosis ... See more keywords
Systems-level organization of non-alcoholic fatty liver disease progression network.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00013h
Abstract: Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex spectrum of diseases ranging from simple steatosis to Non-Alcoholic Steatohepatitis (NASH) with fibrosis, which can progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of NAFLD is complex,… read more here.
Keywords: alcoholic fatty; fatty liver; non alcoholic; nash fibrosis ... See more keywords
Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1442436
Abstract: ABSTRACT Introduction: Nonalcoholic fatty liver disease (NAFLD) has an increasing prevalence worldwide. At present, no specific pharmacotherapy is approved for NAFLD. Simple steatosis and nonalcoholic steatohepatitis (NASH) can progress to liver fibrosis that is associated… read more here.
Keywords: fibrosis; liver fibrosis; treatment; nash fibrosis ... See more keywords
Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis: opportunities and challenges
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2020.1718106
Abstract: In parallel to the obesity pandemic, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in adults worldwide [1]. Especially its inflammatory form, nonalcoholic steatohepatitis (NASH), but ‘simple steatosis’… read more here.
Keywords: fibrosis; nonalcoholic steatohepatitis; liver; steatohepatitis nash ... See more keywords
An integrated analysis of fecal microbiome and metabolomic features distinguish Non-cirrhotic NASH from healthy control populations.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000474
Abstract: There is great interest in identifying microbiome features as reliable noninvasive diagnostic and/or prognostic biomarkers for non-cirrhotic NASH fibrosis. Several cross-sectional studies have reported gut microbiome features associated with advanced NASH fibrosis and cirrhosis, where… read more here.
Keywords: non cirrhotic; microbiome features; cirrhotic nash; nash fibrosis ... See more keywords