Serum Glycoprotein Markers in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00965
Abstract: Fatty liver disease progresses through stages of fat accumulation and inflammation to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and eventually hepatocellular carcinoma (HCC). Currently available diagnostic tools for HCC lack sensitivity and specificity. In this… read more here.
Keywords: hcc; hepatocellular carcinoma; serum; nonalcoholic steatohepatitis ... See more keywords
Microbiota, NASH, HCC and the potential role of probiotics
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DOI: 10.1093/carcin/bgx007
Abstract: Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Clearly identifiable risk factors are lacking in up to 30% of HCC patients and most of these cases are attributed to non-alcoholic fatty liver… read more here.
Keywords: hcc; microbiota; nash hcc; risk factors ... See more keywords
Immature neutrophils bring anti-PD-1 therapy in NASH-HCC to maturity
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DOI: 10.1136/gutjnl-2022-327396
Abstract: immune suppression in the vicinity of tumour cells. Combinatorial treatment of anti- CXCR2 and anti- PD- 1 in NASH- HCC mouse models led to a recruitment of immature neutrophils from the bone marrow into the… read more here.
Keywords: bring anti; nash hcc; immature neutrophils; neutrophils bring ... See more keywords
Dysregulated sphingolipid metabolism contributes to NASH-HCC disease progression
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734514
Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is the fastest-rising cause of end-stage liver disease for liver transplantation. The underlying mechanisms of NAFLD disease progression from nonalcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC) remain unclear. It… read more here.
Keywords: sphingolipid metabolism; disease; nash hcc; hcc ... See more keywords
Differential progression of unhealthy diet-induced hepatocellular carcinoma in obese and non-obese mice
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DOI: 10.1371/journal.pone.0272623
Abstract: Background Non-alcoholic fatty liver disease (NAFLD) ranks first among liver diseases in Western countries. NAFLD is typically associated with obesity and diabetes, however it also develops in lean individuals without metabolic syndrome. The prevalence of… read more here.
Keywords: nash hcc; progression; obese mice; mice ... See more keywords
Comparisons between non-alcoholic steatohepatitis and alcohol-related hepatocellular carcinoma
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DOI: 10.3350/cmh.2019.0012
Abstract: Background/Aims Non-alcoholic liver disease and alcoholic liver disease begin as simple steatosis that may progress to steatohepatitis and ensuing liver-related complications such as cirrhosis and hepatocellular carcinoma (HCC). We explored differences in characteristics between non-alcoholic… read more here.
Keywords: hcc; non alcoholic; ash hcc; nash hcc ... See more keywords
All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102351
Abstract: Cathepsins are lysosomal proteases that are essential to maintain cellular physiological homeostasis and are involved in multiple processes, such as immune and energy regulation. Predominantly, cathepsins reside in the lysosomal compartment; however, they can also… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; role; nash hcc ... See more keywords
Discovering Biomarkers for Non-Alcoholic Steatohepatitis Patients with and without Hepatocellular Carcinoma Using Fecal Metaproteomics
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168841
Abstract: High-calorie diets lead to hepatic steatosis and to the development of non-alcoholic fatty liver disease (NAFLD), which can evolve over many years into the inflammatory form of non-alcoholic steatohepatitis (NASH), posing a risk for the… read more here.
Keywords: hepatocellular carcinoma; non alcoholic; alcoholic steatohepatitis; nash hcc ... See more keywords
Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis
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DOI: 10.3390/ijms24010210
Abstract: With the rising incidence of hepatocellular carcinoma (HCC) from non-alcoholic steatohepatitis (NASH), identifying new metabolic readouts that function in metabolic pathway perpetuation is still a demand. The study aimed to compare the metabolic signature between… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; nash hcc; hcc ... See more keywords
Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.49785
Abstract: Non-alcoholic steatohepatitis (NASH) is a type of nonalcoholic fatty liver disease and has become a major risk factor for hepatocellular carcinoma (HCC). However, the underlying pathophysiological mechanisms are still elusive. Here, we identify hyaluronan-mediated motility… read more here.
Keywords: hepatocellular carcinoma; hcc; nash hcc; cebp ... See more keywords