Assessment of Survival Model Performance Following Inclusion of Epstein-Barr Virus DNA Status in Conventional TNM Staging Groups in Epstein-Barr Virus–Related Nasopharyngeal Carcinoma
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DOI: 10.1001/jamanetworkopen.2021.24721
Abstract: Key Points Question Can incorporating Epstein-Barr virus DNA status into analysis of the tumor-node-metastasis framework improve cancer staging quality in nasopharyngeal carcinoma? Findings In this multicenter prognostic study of 2354 patients in China, a recursive… read more here.
Keywords: barr virus; epstein barr; nasopharyngeal carcinoma; virus dna ... See more keywords
Association of Treatment Advances With Survival Rates in Pediatric Patients With Nasopharyngeal Carcinoma in China, 1989-2020
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DOI: 10.1001/jamanetworkopen.2022.0173
Abstract: This cohort study investigates the association of advances in imaging diagnosis, radiotherapy techniques, and treatment methods with survival among pediatric patients with nasopharyngeal carcinoma in China from 1989 to 2020. read more here.
Keywords: carcinoma china; patients nasopharyngeal; 1989 2020; nasopharyngeal carcinoma ... See more keywords
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.0122
Abstract: Importance Induction chemotherapy added to concurrent chemoradiotherapy significantly improves survival for patients with locoregionally advanced nasopharyngeal carcinoma, but the optimal induction regimen remains unclear. Objective To determine whether induction chemotherapy with paclitaxel, cisplatin, and capecitabine… read more here.
Keywords: nasopharyngeal carcinoma; free survival; induction chemotherapy; cisplatin ... See more keywords
Association of Intratumoral Microbiota With Prognosis in Patients With Nasopharyngeal Carcinoma From 2 Hospitals in China
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2022.2810
Abstract: Key Points Question Is there characteristic microbiota in nasopharyngeal carcinoma (NPC) tissues and, if so, is it associated with prognosis? Findings In this multicenter cohort study including 802 patients with NPC, we confirmed the existence… read more here.
Keywords: nasopharyngeal carcinoma; prognosis; microbiota; intratumoral microbiota ... See more keywords
Downregulation of adipose triglyceride lipase by EB viral‐encoded LMP2A links lipid accumulation to increased migration in nasopharyngeal carcinoma
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DOI: 10.1002/1878-0261.12824
Abstract: Epstein–Barr virus (EBV)‐associated nasopharyngeal carcinoma (NPC) is one of the most common human cancers in South‐East Asia exhibiting typical features of lipid accumulation. EBV‐encoded latent membrane protein 2A (LMP2A) is expressed in most NPCs enhancing… read more here.
Keywords: accumulation; lipid accumulation; migration; downregulation ... See more keywords
Parotid gland radiation dose‐xerostomia relationships based on actual delivered dose for nasopharyngeal carcinoma
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DOI: 10.1002/acm2.12327
Abstract: Abstract Xerostomia induced by radiotherapy is a common toxicity for head and neck carcinoma patients. In this study, the deformable image registration of planning computed tomography (CT) and weekly cone‐beam CT (CBCT) was used to… read more here.
Keywords: radiation dose; planning; delivered dose; xerostomia ... See more keywords
N6‐Methyladenosine‐Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation
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DOI: 10.1002/advs.202205091
Abstract: Epitranscriptomic remodeling such as N6‐methyladenosine (m6A) modification plays a critical role in tumor development. However, little is known about the underlying mechanisms connecting m6A modification and nasopharyngeal carcinoma (NPC) progression. Here, CBX1 is identified, a… read more here.
Keywords: nasopharyngeal carcinoma; progression; cbx1; modified cbx1 ... See more keywords
Clinical utility of Epstein‐Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma
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DOI: 10.1002/cac2.12100
Abstract: Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor ubiquitously associated with the Epstein‐Barr virus (EBV), which is highly prevalent in South China, Southeast Asia, and North Africa. Despite being a highly radio‐sensitive and treatable cancer,… read more here.
Keywords: epstein barr; detection; dna; barr virus ... See more keywords
ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma
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DOI: 10.1002/cam4.1552
Abstract: Rho GTPase‐activating protein 42 was identified as an inhibitor of RhoA to maintain normal blood pressure homeostasis. However, the effect of ARHGAP42 in promoting cell malignancy in nasopharyngeal carcinoma is demonstrated in this study. Microarray… read more here.
Keywords: carcinoma; cell migration; arhgap42; nasopharyngeal carcinoma ... See more keywords
Gemcitabine and cisplatin regimen facilitates prognosis of advanced nasopharyngeal carcinoma
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DOI: 10.1002/cam4.1575
Abstract: This study was conducted to assess the efficacy and adverse effects of GP (gemcitabine + cisplatin) regimen and FP (fluouracil + cisplatin) regimen in treatment of advanced nasopharyngeal carcinoma. Systematic online searches were performed in… read more here.
Keywords: regimen facilitates; gemcitabine cisplatin; cisplatin regimen; advanced nasopharyngeal ... See more keywords
Necessity of concurrent chemotherapy in N2‐3 nasopharyngeal carcinoma treated with neoadjuvant chemotherapy of ≥3 cycles followed by intensity‐modulated radiotherapy
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DOI: 10.1002/cam4.2179
Abstract: Concurrent chemotherapy (CCT) is used in locally advanced nasopharyngeal carcinoma (NPC) for improved local control, which could also be achieved by intensity‐modulated radiotherapy (IMRT). And for N2‐3 NPC, distant metastasis is the more important cause… read more here.
Keywords: chemotherapy; modulated radiotherapy; intensity modulated; concurrent chemotherapy ... See more keywords