Diffusion-limited association of disordered protein by non-native electrostatic interactions
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DOI: 10.1038/s41467-018-06866-y
Abstract: Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins. In contrast to interactions between folded proteins, this additional folding step makes the binding process more complex. Understanding the mechanism of coupled binding and… read more here.
Keywords: limited association; native electrostatic; diffusion limited; electrostatic interactions ... See more keywords
Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1
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DOI: 10.1371/journal.pcbi.1005468
Abstract: PUMA, which belongs to the BH3-only protein family, is an intrinsically disordered protein (IDP). It binds to its cellular partner Mcl-1 through its BH3 motif, which folds upon binding into an α helix. We have… read more here.
Keywords: role non; folding binding; coupled folding; native electrostatic ... See more keywords