Native Ion Mobility-Mass Spectrometry-Enabled Fast Structural Interrogation of Labile Protein Surface Modifications at the Intact Protein Level.
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DOI: 10.1021/acs.analchem.1c04503
Abstract: Protein sialylation has been closely linked to many diseases including Alzheimer's disease (AD). It is also broadly implicated in therapeutics operating in a pattern-dependent (e.g., Neu5Ac vs Neu5Gc) manner. However, how the sialylation pattern affects… read more here.
Keywords: mass spectrometry; sialylation; fast structural; native ion ... See more keywords