Conjugation of a Toll‐Like Receptor Agonist to Glycans of an HIV Native‐Like Envelope Trimer Preserves Neutralization Epitopes
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200236
Abstract: Small molecule adjuvants are attractive for enhancing broad protection and durability of immune responses elicited by subunit vaccines. Covalent attachment of an adjuvant to an immunogen is particularly attractive because it simultaneously delivers both entities… read more here.
Keywords: envelope trimer; native like; toll like; like receptor ... See more keywords
A Flexible, Modular Platform for Multidimensional Ion Mobility of Native-like Ions.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.3c00112
Abstract: Native ion mobility (IM) mass spectrometry (MS) is used to probe the size, shape, and assembly of biomolecular complexes. IM-IM-MS can increase the amount of information available in structural studies by isolating subpopulations of structures… read more here.
Keywords: native like; platform; ion mobility; like ions ... See more keywords
Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ vaccines"
DOI: 10.1038/s41541-020-00219-x
Abstract: Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeutics or vaccines against… read more here.
Keywords: surface glycoprotein; virus like; like particles; envelope surface ... See more keywords
A bioinspired glycopolymer for capturing membrane proteins in native-like lipid-bilayer nanodiscs.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr03811g
Abstract: Amphiphilic copolymers that directly extract membrane proteins and lipids from cellular membranes to form nanodiscs combine the advantages of harsher membrane mimics with those of a native-like membrane environment. Among the few commercial polymers that… read more here.
Keywords: native like; bioinspired glycopolymer; membrane proteins; like lipid ... See more keywords
Hydrogen/deuterium exchange-mass spectrometry of integral membrane proteins in native-like environments: current scenario and the way forward
Sign Up to like & getrecommendations! Published in 2023 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220173
Abstract: Abstract Integral membrane proteins (IMPs) perform a range of diverse functions and their dysfunction underlies numerous pathological conditions. Consequently, IMPs constitute most drug targets, and the elucidation of their mechanism of action has become an… read more here.
Keywords: integral membrane; native like; membrane proteins; hydrogen deuterium ... See more keywords
Using more native-like language acquisition processes in the foreign language classroom
Sign Up to like & getrecommendations! Published in 2018 at "Cogent Education"
DOI: 10.1080/2331186x.2018.1429134
Abstract: Abstract This work presents the case for using native-like language and learning networks in the classroom-based teaching of foreign languages and suggests how this might be done for EFL lessons. Networks in both syntax and… read more here.
Keywords: classroom; like language; using native; syntax ... See more keywords
Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00677-17
Abstract: ABSTRACT Native-like trimers of the SOSIP design are being developed as immunogens in human immunodeficiency virus type 1 (HIV-1) vaccine development programs. These trimers display the epitopes for multiple broadly neutralizing antibodies (bNAbs) but can… read more here.
Keywords: immunogenicity; sosip; hiv; sosip trimers ... See more keywords
Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01025
Abstract: Germline precursors and intermediates of broadly neutralizing antibodies (bNAbs) are essential to the understanding of humoral response to HIV-1 infection and B-cell lineage vaccine design. Using a native-like gp140 trimer probe, we examined antibody libraries… read more here.
Keywords: lineage; hiv; broadly neutralizing; digital panning ... See more keywords
Reliable Generation of Native-Like Decoys Limits Predictive Ability in Fragment-Based Protein Structure Prediction
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecules"
DOI: 10.3390/biom9100612
Abstract: Our previous work with fragment-assembly methods has demonstrated specific deficiencies in conformational sampling behaviour that, when addressed through improved sampling algorithms, can lead to more reliable prediction of tertiary protein structure when good fragments are… read more here.
Keywords: like decoys; protein structure; fragment based; prediction ... See more keywords