Quantitative and Structural Assessment of Histone Methyllysine Analogue Engagement by Cognate Binding Proteins Reveals Affinity Decrements Relative to Those of Native Counterparts.
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DOI: 10.1021/acs.biochem.7b00926
Abstract: Methyllysine analogues (MLAs), furnished by aminoethylation of engineered cysteine residues, are widely used surrogates of histone methyllysine and are considered to be effective proxies for studying these epigenetic marks in vitro. Here we report the… read more here.
Keywords: histone methyllysine; native methyllysine; affinity; methyllysine ... See more keywords