In silico design and computational evaluation of novel 2-arylaminopyrimidine-based compounds as potential multi-targeted protein kinase inhibitors: application for the native and mutant (T315I) Bcr-Abl tyrosine kinase
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DOI: 10.1080/07391102.2022.2062784
Abstract: Abstract An integrated computational approach to drug discovery was used to identify novel potential inhibitors of the native and mutant (T315I) Bcr-Abl tyrosine kinase, the enzyme playing a key role in the pathogenesis of chronic… read more here.
Keywords: mutant t315i; kinase; native mutant; t315i bcr ... See more keywords