Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105988
Abstract: Myocardial ischemia-reperfusion (I/R) is a severe disease，but its underlying mechanism is not fully elucidated and no effective clinical treatment is available. Utilizing intracellular peptidomics, we identified a novel native peptide PDRL23A (Peptide Derived from RPL23A),… read more here.
Keywords: protein; peptide; myocardial ischemia; native peptide ... See more keywords
Emergence of native peptide sequences in prebiotic replication networks
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00463-1
Abstract: Biopolymer syntheses in living cells are perfected by an elaborate error correction machinery, which was not applicable during polymerization on early Earth. Scientists are consequently striving to identify mechanisms by which functional polymers were selected… read more here.
Keywords: peptide sequences; sequences prebiotic; prebiotic replication; native peptide ... See more keywords
Native peptide mapping – A simple method to routinely monitor higher order structure changes and relation to functional activity
Sign Up to like & getrecommendations! Published in 2019 at "mAbs"
DOI: 10.1080/19420862.2019.1634460
Abstract: ABSTRACT In the biopharmaceutical environment, controlling the Critical Quality Attributes (CQA) of a product is essential to prevent changes that affect its safety or efficacy. Physico-chemical techniques and bioassays are used to screen and monitor… read more here.
Keywords: higher order; structure; peptide mapping; activity ... See more keywords