Peroxidase Activity of a c‐Type Cytochrome b 5 in the Non‐Native State is Comparable to that of Native Peroxidases
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DOI: 10.1002/open.201700055
Abstract: Abstract The design of artificial metalloenzymes has achieved tremendous progress, although few designs can achieve catalytic performances comparable to that of native enzymes. Moreover, the structure and function of artificial metalloenzymes in non‐native states has… read more here.
Keywords: peroxidase; native state; type cytochrome; comparable native ... See more keywords
Exploring the Levinthal limit in protein folding
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DOI: 10.1007/s10867-016-9431-6
Abstract: According to the thermodynamic hypothesis, the native state of proteins is uniquely defined by their amino acid sequence. On the other hand, according to Levinthal, the native state is just a local minimum of the… read more here.
Keywords: levinthal limit; native state; protein folding;
Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.
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DOI: 10.1016/j.str.2021.10.001
Abstract: Peroxiredoxins are ubiquitous enzymes that detoxify peroxides and regulate redox signaling. During catalysis, a "peroxidatic" cysteine (CP) in the conserved active site reduces peroxide while being oxidized to a CP-sulfenate, prompting a local unfolding event… read more here.
Keywords: native state; local unfolding; catalysis; active site ... See more keywords
Cryo-OrbiSIMS for 3D molecular imaging of a bacterial biofilm in its native state.
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DOI: 10.1021/acs.analchem.0c01125
Abstract: Secondary ion mass spectrometry (SIMS) is gaining popularity for molecular imaging in the life-sciences since it is label-free and allows imaging in two and three dimensions. The recent introduction of the OrbiSIMS has significantly improved… read more here.
Keywords: state; native state; mass; biofilm native ... See more keywords
The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
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DOI: 10.1038/s41598-017-00710-x
Abstract: The conversion of globular proteins into amyloid fibrils is associated with a wide variety of human diseases. One example is the prion protein (PrP), which adopts an α-helical structure in the native state but its… read more here.
Keywords: state; native state; prion; formation ... See more keywords