Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00516
Abstract: Telomerase is an enzyme deputed to the maintenance of eukaryotic chromosomes; however, its overexpression is a recognized hallmark of many cancer forms. A viable route for the inhibition of telomerase in malignant cells is the… read more here.
Keywords: human telomeric; berberine human; natural alkaloid; pyridine derivative ... See more keywords
Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2018.1540599
Abstract: Abstract Dozens of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones were synthesized in a straightforward method by condensation of substituted 2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-diones or N-methyl-2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-dione with 3,4-dihydro-β-carbolines. In vitro cytotoxic assay discovered that compounds 9a,… read more here.
Keywords: thieno pyrimidinones; natural alkaloid; hybrids natural; alkaloid evodiamine ... See more keywords
Epibatidine: A Promising Natural Alkaloid in Health
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DOI: 10.3390/biom9010006
Abstract: Epibatidine is a natural alkaloid that acts at nicotinic acetylcholine receptors (nAChRs). The present review aims to carefully discuss the affinity of epibatidine and its synthetic derivatives, analogues to nAChRs for α4β2 subtype, pharmacokinetic parameters,… read more here.
Keywords: alkaloid health; natural alkaloid; epibatidine promising; promising natural ... See more keywords
The Natural Alkaloid Tryptanthrin Induces Apoptosis-like Death in Leishmania spp.
Sign Up to like & getrecommendations! Published in 2022 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed7060112
Abstract: Leishmaniasis is a vector-borne disease against which there are no approved vaccines, and the treatment is based on highly toxic drugs. The alkaloids consist of a chemical class of natural nitrogen-containing substances with a long… read more here.
Keywords: natural alkaloid; like death; leishmania; tryptanthrin ... See more keywords