Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.047
Abstract: The biggest challenge associated with cancer chemotherapy is the development of cross multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major contributing factor for this resistance is efflux of the drugs by… read more here.
Keywords: reversal cancer; natural alkaloids; resistance reversal; resistance ... See more keywords
Natural alkaloids intervening the insulin pathway: new hopes for anti-diabetic agents?
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180430152618
Abstract: BACKGROUND Accumulating experimental data support the capacity of natural compounds to intervene in complicated molecular pathways underlying the pathogenesis of certain human morbidities. Among them, diabetes is now a world's epidemic associated with increased risk… read more here.
Keywords: insulin; natural alkaloids; alkaloids intervening; diabetic agents ... See more keywords
Effects and mechanisms of natural alkaloids for prevention and treatment of osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1014173
Abstract: Natural alkaloids are polycyclic, nitrogen-containing, and basic compounds obtained from plants. In this review, the advances in bioactive alkaloids with respect to their chemical structures, herbal sources, and effects for the prevention and treatment of… read more here.
Keywords: treatment osteoporosis; prevention treatment; natural alkaloids; osteoporosis ... See more keywords