Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation.
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DOI: 10.1016/j.ijbiomac.2016.12.025
Abstract: Akt, a serine/threonine protein kinase, is often hyper activated in breast and prostate cancers, but with poor prognosis. Allosteric inhibitors regulate aberrant kinase activity by stabilizing the protein in inactive conformation. Several natural compounds have… read more here.
Keywords: allosteric inhibitor; inactive conformation; natural allosteric; inhibitor akt1 ... See more keywords