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   Articles with "natural amino" as a keyword



Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation

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recommendations! Published in 2018 at "Applied Organometallic Chemistry"

DOI: 10.1002/aoc.4069

Abstract: We report the synthesis of iron oxide magnetic nanoparticles (IONPs) coated with various natural amino acids (AAs) using a one-pot reaction in an aqueous medium. Several AAs, which contained hydrophilic and hydrophobic groups, were selected… read more here.

Keywords: natural amino; amino acids; iron oxide; magnetic nanoparticles ... See more keywords

Stabilization of Angiotensin-(1–7) by key substitution with a cyclic non-natural amino acid

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recommendations! Published in 2017 at "Amino Acids"

DOI: 10.1007/s00726-017-2471-9

Abstract: Angiotensin-(1–7) [Ang-(1–7)], a heptapeptide hormone of the renin–angiotensin–aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide’s therapeutic potential is limited by the short… read more here.

Keywords: natural amino; amino; amino acid; cyclic non ... See more keywords
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Bio-functionalizing of α-MnO2 nanorods with natural l-amino acids: A favorable adsorbent for the removal of Cd(II) ions

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recommendations! Published in 2017 at "Materials Chemistry and Physics"

DOI: 10.1016/j.matchemphys.2017.01.040

Abstract: Abstract α-MnO 2 nanorods were prepared by hydrothermal method and then the surface of these nanorods were covalently biofunctionalized with natural l -amino acids (alanine, phenylalanine, leucine, isoleucine, methionine, and valine). The modified α-MnO 2… read more here.

Keywords: natural amino; amino acids; microscopy; functionalizing mno2 ... See more keywords

Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag.

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recommendations! Published in 2018 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.8b00284

Abstract: The high specificity and favorable pharmacological properties of monoclonal antibodies (mAbs) have prompted significant interest in re-engineering this class of molecules to add novel functionalities for enhanced therapeutic and diagnostic potential. Here, we used the… read more here.

Keywords: natural amino; monoclonal antibodies; template; chemistry ... See more keywords

Enhanced Codon-Anticodon Interaction at In-Frame UAG Stop Codon Improves the Efficiency of Non-Natural Amino Acid Mutagenesis.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.1c00782

Abstract: The introduction of non-natural amino acids into proteins through the stop codon readthrough methodology has been used to design proteins for diverse applications. However, this method suffers from low yields of the modified protein, as… read more here.

Keywords: natural amino; interaction; codon; stop codon ... See more keywords

Natural Amino Acid-Derived Iron(III) Catalysts for Green Oxidation Chemistry Applications

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c05723

Abstract: Iron-complex peroxide activators make up a group of catalysts developed to perform green oxidation chemistries. They are among the most efficient, environmentally friendly oxidants, but several structural challenges limit their wider applications. In this study,… read more here.

Keywords: iron; chemistry; natural amino; green oxidation ... See more keywords

Enzyme stabilisation due to incorporation of a fluorinated non-natural amino acid at the protein surface

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-79711-6

Abstract: We have previously engineered E. coli transketolase (TK) enzyme variants that accept new substrates such as aliphatic or aromatic aldehydes, and also with improved thermal stability. Irreversible aggregation is the primary mechanism of deactivation for… read more here.

Keywords: non natural; site; protein; phe ... See more keywords

PepINVENT: generative peptide design beyond natural amino acids

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recommendations! Published in 2024 at "Chemical Science"

DOI: 10.1039/d4sc07642g

Abstract: Peptides play a crucial role in drug design and discovery whether as a therapeutic modality or a delivery agent. Non-natural amino acids (NNAAs) have been used to enhance the peptide properties such as binding affinity,… read more here.

Keywords: space; amino acids; peptide; natural amino ... See more keywords

From concept to chemistry: integrating protection group strategy and reaction feasibility into non-natural amino acid synthesis planning

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recommendations! Published in 2025 at "Chemical Science"

DOI: 10.1039/d5sc04898b

Abstract: Incorporating non-natural amino acids (NNAAs) into peptides enhances therapeutic properties, including binding affinity, metabolic stability, and in vivo half-life time. The pursuit of novel NNAAs for improved peptide designs faces the challenge of effective synthesis… read more here.

Keywords: protection; non natural; chemistry; synthesis ... See more keywords
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Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

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recommendations! Published in 2021 at "Biomolecules"

DOI: 10.3390/biom11030421

Abstract: Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using unique… read more here.

Keywords: trp; natural amino; amino acid; non natural ... See more keywords

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

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recommendations! Published in 2024 at "Marine Drugs"

DOI: 10.3390/md22030110

Abstract: α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of α-CTxs have been demonstrated with… read more here.

Keywords: non natural; peia; acetylcholine receptors; amino ... See more keywords