High-Order Quantum-Mechanical Analysis of Hydrogen Bonding in Hachimoji and Natural DNA Base Pairs
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.3c00428
Abstract: High-order quantum chemistry is applied to hydrogen-bonded natural DNA nucleobase pairs [adenine:thymine (A:T) and guanine:cytosine (G:C)] and non-natural Hachimoji nucleobase pairs [isoguanine:1-methylcytosine (B:S) and 2-aminoimidazo[1,2a][1,3,5]triazin-4(1H)-one:6-amino-5-nitropyridin-2-one (P:Z)] to see how the intermolecular interaction energies and their… read more here.
Keywords: base pairs; high order; order quantum; natural dna ... See more keywords
The crystal structure of a natural DNA polymerase complexed with mirror DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc09351f
Abstract: The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer… read more here.
Keywords: crystal structure; dna; dna polymerase; natural dna ... See more keywords
Natural DNA Intercalators as Promising Therapeutics for Cancer and Infectious Diseases.
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DOI: 10.2174/1568009619666191007112516
Abstract: Cancer and infectious diseases are one of the greatest challenges of modern medicine. An unhealthy lifestyle, the improper use of drugs or their abuse are conducive to the increase of morbidity and mortality caused by… read more here.
Keywords: infectious diseases; dna intercalators; natural dna; cancer infectious ... See more keywords