Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits
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DOI: 10.1016/j.neuron.2019.05.050
Abstract: Motivated behavior is influenced by neural networks that integrate physiological needs. Here, we describe coordinated regulation of hypothalamic feeding and midbrain reward circuits in awake behaving mice. We find that alcohol and other non-nutritive drugs… read more here.
Keywords: natural drug; rewards engage; reward circuits; drug rewards ... See more keywords
Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.12.016
Abstract: The mesolimbic dopamine (DA) system reinforces behaviors that are critical for survival. However, drug dependence can occur when drugs of abuse, such as nicotine, highjack this reinforcement system. Pharmacologically targeting the DA system to selectively… read more here.
Keywords: system; drug; natural drug; specificity varenicline ... See more keywords
Synthesis and in vitro evaluation of natural drug loaded polymeric films for cardiovascular applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bioactive and Compatible Polymers"
DOI: 10.1177/08839115221085735
Abstract: Drug eluting stents (DES) can efficiently reduce the atherosclerosis and restenosis issues of coronary artery as compared to bare metal stents due to the presence of pharmaceutically active agent on their surface. Nevertheless, the arising… read more here.
Keywords: natural drug; polymeric films; drug loaded; synthesis vitro ... See more keywords
Targets preliminary screening for the fresh natural drug molecule based on Cosine-correlation and similarity-comparison of local network
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-022-03279-w
Abstract: Background Chinese herbal medicine is made up of hundreds of natural drug molecules and has played a major role in traditional Chinese medicine (TCM) for several thousand years. Therefore, it is of great significance to… read more here.
Keywords: drug; fresh natural; medicine; natural drug ... See more keywords
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
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DOI: 10.3390/ijms22020778
Abstract: Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in… read more here.
Keywords: cannabis; natural drug; sativa natural; treatment ... See more keywords