Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28777
Abstract: Flavonoids comprise a group of natural polyphenols consisting of more than 5,000 subtypes mostly existing in fruits and vegetables. Flavonoids consumption could potentially attenuate the incidence and recurrence risk of colorectal cancers through their antiperoxidative,… read more here.
Keywords: natural flavonoids; flavonoids prevention; colon cancer; cancer ... See more keywords
Research Progress of the Antiviral Bioactivities of Natural Flavonoids
Sign Up to like & getrecommendations! Published in 2020 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-020-00257-x
Abstract: Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated… read more here.
Keywords: natural flavonoids; antiviral bioactivities; bioactivities natural; progress antiviral ... See more keywords
Structural and functional insights into RHA-P, a bacterial GH106 α-L-rhamnosidase from Novosphingobium sp. PP1Y.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.04.013
Abstract: α-L-Rhamnosidases (α-RHAs, EC 3.2.1.40) are glycosyl hydrolases (GHs) hydrolyzing terminal α-l-rhamnose residues from different substrates such as heteropolysaccharides, glycosylated proteins and natural flavonoids. Although the possibility to hydrolyze rhamnose from natural flavonoids has boosted the… read more here.
Keywords: natural flavonoids; functional insights; novosphingobium pp1y; structural functional ... See more keywords
The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.057
Abstract: β-Glucuronidase plays a vital role in the metabolism of drug and endogenous substance. Herein, we assayed the inhibitory effects of thirty-six flavonoids (1-36) toward β-glucuronidase (Escherichia coli) using the probe reaction of DDAO-glu hydrolysis. The… read more here.
Keywords: natural flavonoids; toward glucuronidase; flavonoids toward; glucuronidase ... See more keywords
Discovery of novel natural flavonoids as potent antiviral candidates against hepatitis C virus NS5B polymerase.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109359
Abstract: The non-structural 5B (NS5B) polymerase of hepatitis C virus (HCV) is an attractive target for antiviral intervention. Quercetagetin (Que) is a natural flavonoid, which has been exhibited to have anti-HCV property through inhibition of RNA… read more here.
Keywords: natural flavonoids; ns5b polymerase; que; hepatitis virus ... See more keywords
Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.130950
Abstract: Abstract Natural flavonoids and flavonoid glycosides exist in many plants and have been demonstrated to possess various clinically relevant properties, isolating large amounts of these compounds that have striking structural similarity from plant sources needs… read more here.
Keywords: natural flavonoids; flavonoids flavonoid; series natural; flavonoid glycosides ... See more keywords
Identification of structural requirements and prediction of inhibitory activity of natural flavonoids against Zika virus through molecular docking and Monte Carlo based QSAR Simulation
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1413574
Abstract: Abstract There has been growing interest in the research of flavonoids due to their potential antiviral activities. Recently, some natural flavonoids have shown potential inhibitory activity against zika virus NS3–NS2B protease. In order to accelerate… read more here.
Keywords: natural flavonoids; monte carlo; zika virus; inhibitory activity ... See more keywords
Inhibition of transmembrane member 16A calcium‐activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13841
Abstract: Natural flavonoids are ubiquitous in dietary plants and vegetables and have been proposed to have antiviral, antioxidant, cardiovascular protective and anticancer effects. Transmembrane member 16A (TMEM16A)‐encoded Ca2+‐activated Cl− channels play a variety of physiological roles… read more here.
Keywords: natural flavonoids; member 16a; transmembrane member; anticancer effects ... See more keywords
Anti‐microbial efficacy, mechanisms and druggability evaluation of the natural flavonoids
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15705
Abstract: This study was conducted to evaluate 35 natural flavonoids for their in vitro susceptibility against E. coli (ATCC 25922), Ps. aeruginosa (ATCC 27853), B. subtilis (ATCC 530) and Staph. aureus (ATCC 6538) in search of… read more here.
Keywords: druggability evaluation; mechanisms druggability; efficacy mechanisms; natural flavonoids ... See more keywords
Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Current Organic Chemistry"
DOI: 10.2174/1385272823666191203122030
Abstract: Rapid tumor growth is dependent on the capability of tumor blood vessels and glycolysis to provide oxygen and nutrients. Tumor hypoxia is a common characteristic of many solid tumors, and it essentially happens when the… read more here.
Keywords: natural flavonoids; inhibition hif; anticancer activity; tumor ... See more keywords
The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1117489
Abstract: Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for treating OA.… read more here.
Keywords: targeting signaling; natural flavonoids; signaling pathway; protective activity ... See more keywords