New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense.
Sign Up to like & getrecommendations! Published in 2018 at "Fitoterapia"
DOI: 10.1016/j.fitote.2018.01.001
Abstract: Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its… read more here.
Keywords: natural inhibitors; ganoderma sinense; inhibitors hexokinase; new natural ... See more keywords
Screening natural inhibitors against upregulated G-protein coupled receptors as potential therapeutics of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1817784
Abstract: Abstract Computational approaches have been helpful in high throughput screening of drug libraries and designing ligands against receptors. Alzheimer's disease is a complex neurological disorder, which causes dementia. In this disease neurons are damaged due… read more here.
Keywords: inhibitors upregulated; upregulated protein; screening natural; natural inhibitors ... See more keywords
Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer’s rat model
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2164617
Abstract: Abstract Background: Phytochemicals have amazing biological effects in relation to age-related illnesses and are increasingly being studied in clinical trials. The goal of this study was to examine the effectiveness of the aqueous extracts of… read more here.
Keywords: rat model; alzheimer rat; tau amyloid; natural inhibitors ... See more keywords
Novel natural inhibitors targeting KRAS G12C by computational study
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001317
Abstract: Ideal leading and nominee compounds with inhibiting effects on KRAS G12C were selected from the ZINC database, laying a cornerstone for the progress of anticancer drugs. A variety of computational virtual screening methods were utilized… read more here.
Keywords: kras g12c; inhibitors targeting; zinc000012494057 zinc000003789195; natural inhibitors ... See more keywords
Exploring the targets of novel corona virus and docking-based screening of potential natural inhibitors to combat COVID-19.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666221020163831
Abstract: There is a need to explore natural compounds against COVID-19 due to their multi-targeted actions against various targets of nCoV. They act on multiple sites rather than single targets against several diseases. Thus, there is… read more here.
Keywords: inhibitors combat; combat covid; natural inhibitors; based screening ... See more keywords
In silico analysis of natural inhibitors against HPV E6 protein.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230310144550
Abstract: BACKGROUND Drug re-purposing is one of the cost-effective methods to establish novel therapeutics against many diseases. Established natural products are collected from databases and used to potentially screen them against HPV E6 protein, a critical… read more here.
Keywords: analysis natural; silico analysis; natural inhibitors; analysis ... See more keywords
Natural inhibitors: A sustainable way to combat aflatoxins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.993834
Abstract: Among a few hundred mycotoxins, aflatoxins had always posed a major threat to the world. Apart from A. flavus, A. parasiticus, and A. nomius of Aspergillus genus, which are most toxin-producing strains, several fungal bodies… read more here.
Keywords: natural inhibitors; inhibitors sustainable; sustainable way; aflatoxin ... See more keywords
Filamentous Thermosensitive Mutant Z: An Appealing Target for Emerging Pathogens and a Trek on Its Natural Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11050624
Abstract: Simple Summary Antimicrobial resistance (AMR) is a pressing issue worldwide that must be addressed swiftly. It is driven by spontaneous evolution, bacterial mutation, and the dissemination of resistant genes via horizontal gene transfer. Researchers are… read more here.
Keywords: mutant appealing; natural inhibitors; filamentous thermosensitive; target ... See more keywords
Natural Inhibitors of Cholinesterases: Chemistry, Structure–Activity and Methods of Their Analysis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032722
Abstract: This article aims to provide an updated description and comparison of the data currently available in the literature (from the last 15 years) on the studied natural inhibitors of cholinesterases (IChEs), namely, acetylcholinesterase (AChE) and… read more here.
Keywords: structure activity; chemistry; natural inhibitors; activity ... See more keywords
Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044140
Abstract: Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms,… read more here.
Keywords: acute myeloid; myeloid leukemia; inhibitors glycoprotein; natural inhibitors ... See more keywords
Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111692
Abstract: It is well known that carbohydrates are the main source of calories in most diets. However, by inhibiting carbohydrases, intake of calories is reduced and weight loss is improved. α-amylase is an enzyme that hydrolyses… read more here.
Keywords: inhibitors amylase; polyphenols natural; amylase glucosidase; natural inhibitors ... See more keywords